نتایج جستجو برای: cardiac damage

تعداد نتایج: 493953  

Journal: :Circulation 2001
Y Y Li D Chen S C Watkins A M Feldman

BACKGROUND Recent studies suggest that mutations in cardiac mitochondrial DNA (mtDNA) may contribute to the development of dilated cardiomyopathy. The mechanisms that regulate those mutations, however, remain undefined. Thus, we studied cardiac mtDNA repair mechanisms, mtDNA damage, and mitochondrial structure and function in mice with heart failure secondary to overexpression of TNF-alpha (TNF...

2017
Fernanda S Hackenhaar Tássia M Medeiros Fernanda M Heemann Camile S Behling Jordana S Putti Camila D Mahl Cleber Verona Ana Carolina A da Silva Maria C Guerra Carlos A S Gonçalves Vanessa M Oliveira Diego F M Riveiro Silvia R R Vieira Mara S Benfato

After cardiac arrest, organ damage consequent to ischemia-reperfusion has been attributed to oxidative stress. Mild therapeutic hypothermia has been applied to reduce this damage, and it may reduce oxidative damage as well. This study aimed to compare oxidative damage and antioxidant defenses in patients treated with controlled normothermia versus mild therapeutic hypothermia during postcardiac...

2014
Sehwan Jang Sabzali Javadov

c-Jun N-terminal kinase (JNK), a stress-activated MAPK, is activated during cardiac ischemia-reperfusion (IR). The role of JNK inhibitors in cardioprotection against IR still remains controversial, in part, due to spill-over effects of non-specific inhibitors. In the present study, we sought to examine whether inhibition of JNK by SU3327, a specific JNK inhibitor that inhibits upstream JNK sign...

Journal: :American journal of physiology. Heart and circulatory physiology 2009
Cameron S Metcalf Steven Poelzing Jason G Little Steven L Bealer

Status epilepticus (SE) is a seizure or series of seizures that persist for >30 min and often results in mortality. Death rarely occurs during or immediately following seizure activity, but usually within 30 days. Although ventricular arrhythmias have been implicated in SE-related mortality, the effects of this prolonged seizure activity on the cardiac function and susceptibility to arrhythmias...

Journal: :Cardiorenal medicine 2011
Dinko Susic Edward D Frohlich

This brief review discusses some aspects of hypertensive damage to the kidneys and cardiovascular system. A comparison of renal and cardiac manifestations of hypertensive disease between results of clinical and experimental studies was made, with a major focus on the possible role of salt and the renin-angiotensin system (RAS) in inducing target organ damage. Thus, some degree of renal impairme...

Journal: :Journal of the American College of Cardiology 2016

Journal: :"Arterial’naya Gipertenziya" ("Arterial Hypertension") 2020

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