We examined the effect of eccentric exercise on the transcriptome of skeletal muscle in three male human volunteers who performed 300 concentric contractions with one leg and 300 eccentric contractions with the opposite leg. Vastus lateralis muscle biopsies were taken from both legs at 4-8 h after exercise, and expression was profiled by using 12000 gene Affymetrix U95Av2 microarrays. We found ...

BURNS, JOHN W., AND JAMES W. COVELL. Myocardial oxygen consumption during isotonic and isovolumic contractions in the intact heart. Am. J. Physiol. 223(6): 1491-1497. 1972.-There is now substantial evidence that the oxygen cost of performing external cardiac work is less than that associated with the development of active tension. However, because of the complex geometry of the contracting hear...

Background: Arterial cannulation and intra-arterial (IA) fluid and blood resuscitation in the patients with severe shock is an easier approach compared with the intravenous (IV) access if concerns regarding the efficiency and safety of this approach are addressed. Objectives: We hypothesized that IA fluid resuscitation is more effective than IV resuscitation in restoring cardiac contractions (C...

The adult spleen is a source of early hematopoietic stem cells (HSC). We therefore studied whether culturing spleen or bone marrow (BM) HSC in medium containing 5-azacytidine could induce a cardiac phenotype. c-kit enrichment and depletion of adult pig spleen and BM mononuclear cells were obtained by magnetic bead separation using biotinylated pig stem cell factor (c-kit ligand). Cells were inc...

About 3,000 individuals in the United States are awaiting a donor heart; worldwide, 22 million individuals are living with heart failure. A bioartificial heart is a theoretical alternative to transplantation or mechanical left ventricular support. Generating a bioartificial heart requires engineering of cardiac architecture, appropriate cellular constituents and pump function. We decellularized...

Anaphylactic shock in the dog, caused by the intravenous injection of horse serum into sensitized animals, may produce definite cardiac disturbances which are revealed by the electrocardiogram. These cardiac changes consist of disturbances in conduction of the heart impulses, abnormalities in the ventricular contractions, and other unusual disturbances of the mechanism of the heart-beat. They c...

Disturbances of impulse formation and conduction may occur anywhere in the human heart. The most common cardiac arrhythmia is the ventricular premature beat. Premature beats may be atrial, atrioventricular (A-V) junctional or ventricular in origin, and may be found in apparently healthy individuals. However, premature beats may become clinically significant if they occur too frequently, origina...

in this paper we discuss on the fixed points of asymptotic contractions and boyd-wong type contractions in uniform spaces equipped with an e-distance. a new version ofkirk's fixed point theorem is given for asymptotic contractions and boyd-wong type contractions is investigated in uniform spaces.