The sunlight was one of the first agents recognized to be carcinogenic for humans. There is convincing evidence from epidemiologic studies that exposure to solar radiation is the major cause of cutaneous melanoma in light-pigmented populations and plays a role in the increasing incidence of this malignancy. The molecular mechanisms by which UV radiation exerts its varied effects are not complet...

More than 90% of worldwide estimated human papillomavirus (HPV)-related cancer mortalities are secondary to invasive cervical cancer (Cutts et al., 2007). There are sufficient evidences to conclude that cervical cancer are virtually caused by complicated infection with high-risk (HR) or carcinogenic types of HPV. According to the recent classification proposed by the International Agency for Re...

14 For some time, there has been an effort made to identify and evaluate dietary components and chemical compounds (chemopreventive agents) that could prevent, inhibit or change the course of colorectal (CR) carcinogenesis (1). These efforts were based on clinical and lay observations, beliefs and epidemiological correlations, that certain foods or additives had beneficial anti-carcinogenic pro...

The effect of different carcinogenic agents on the rate of semiconservative DNA replication in normal and ataxia telangiectasis (AT) cells was investigated. The rate of DNA synthesis in all AT cell strains tested was depressed to a significantly lesser extent than in normal cells after exposure to X-rays under oxia or hypoxia or to bleomycin, agents to which AT cells are hypersensitive. In cont...

The effect of different carcinogenic agents on the rate of semiconservative DNA replication in normal human and ataxia telangiectasia (AT) cells was investigated. The rate of DNA synthesis in all AT cell strains tested was depressed to a significantly lesser extent than in normal cells after exposure to X-rays under oxia or hypoxia or to bleomycin, agents to which AT cells are hypersensitive. I...

background: the present study investigated the impact of land use on health risks (cancerous and non-cancerous) of heavy metals in soil along the hemmat highway of tehran, iran. materials and methods: a total of 28 soil samples were collected in august 2014 from the roadside soil of the hemmat highway. the collected samples were air-dried and digested, and then, analyzed for heavy metals using ...

Cancer is an environmental disease. Carcinogenic agents are extensively spread throughout the environment, inclusive of all the elements in which we live. Therefore all agents, of any type, which come in contact with the human body, are defined environmental agents. They include carcinogens in the air, in the water and in food. In addition there are all those agents which form part of our daily...

BACKGROUND Identifying cancer hazards is the first step towards cancer prevention. The International Agency for Research on Cancer (IARC) Monographs Programme, which has evaluated nearly 1,000 agents for their carcinogenic potential since 1971, typically selects agents for hazard identification on the basis of public nominations, expert advice, published data on carcinogenicity, and public heal...

O-Methylguanine (OmeG) is one of the most toxic, mutagenic, and carcinogenic lesions caused by the interaction of DNA with several catabolism products as well as with environmental methylating agents. Carcinogenic impact of OmeG can be conditioned not only by its mutagenic properties but also by alteration in enzymatic methylation of the C5 carbon atom of cytosine residue in CpG sequences. In t...