The carboxylic acid residue in the title compound, C(6)H(4)BrNO(2), is twisted out of the plane of the other atoms, as indicated by the (Br)C-C-C-O(carbon-yl) torsion angle of -20.1 (9)°. In the crystal, supra-molecular chains mediated by O-H⋯N hydrogen bonds are formed with base vector [201] and C-H⋯O inter-actions reinforce the packing.

In the title compound, C(5)H(5)NO(3), the mol-ecule lies on a crystallographic mirror plane with one half-mol-ecule in the asymmetric unit. An intramolecular C-H⋯O inter-action is present. In the crystal, strong inter-molecular O-H⋯N hydrogen bonds result in the formation of a linear chain structure along [100], and there are also weak C-H⋯O hydrogen bonds between the chains which help to stabi...

A series of novel N-benzyl substituted amides of 1H-indole-5-carboxylic acid were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The target compounds (6b-6e) displayed moderate potency to inhibit BuChE. One of the compounds tested, i.e., 1-benzylpiperidine amide of 1H-indole-5-carboxylic acid (6a) was a weak, non-selective i...

The crystal structures of 7,7-dicyclobutyl-5-hydroxymethyl-6-oxabicyclo[3.2.1]octane-1-carboxylic acid, C17H26O4, (I), and 1-(hydroxymethyl)-7-oxaspiro[bicyclo[3.2.1]octane-6,1'-cyclopentane]-5-carboxylic acid, C13H20O4, (II), determined at 170 K, show that the conformation of the hydroxymethyl group (anti or gauche) affects the dimensionality (one- or two-dimensional) of the supramolecular str...

We discovered on the chromosome of Saccharomyces cerevisiae Sigma 1278b novel genes involved in L-proline analogue L-azetidine-2-carboxylic acid resistance which are not present in the standard laboratory strains. The 5.4 kb-DNA fragment was cloned from the genomic library of the L-azetidine-2-carboxylic acid-resistant mutant derived from a cross between S. cerevisiae strains S288C and Sigma 12...

Solvent extraction is the most widely used method for separation and purification of rare earth elements, organic extractants such as di(2-ethylhexyl) phosphoric acid (P204) di(1-methyl-heptyl) methyl phosphonate (P350) are commonly industrial applications. However, presence impurity ions in feed liquid during can easily emulsify extractant affect quality products. Aluminum ion common liquid, i...

Single carbon to 18 carbon n-aliphatic carboxylic acids were tested for their attractive effects on female Aedes aegypti in a Y-tube olfactometer. Each acid was tested over a wide range of concentrations together with L-(+)-lactic acid, the indispensable synergist for other attractive components emitted from human hosts. The attractiveness of lactic acid was significantly augmented when combine...

A sensitive and reliable method is described for the determination of ochratoxin A (OTA) in maize. An extraction and clean-up procedure was used, with chloroform-phosphoric acid as the extractant, and liquid-liquid partition and anion-exchange chromatography (SAX columns) for the clean-up. Quantification of toxin is achieved by high performance liquid chromatography (HPLC). Recoveries were betw...

Substituted [1,4]thiazepino[2,3-h]quinolinecarboxylic acid 3 is prepared by PPA-catalyzed thermal lactamization of the respective 8-amino-7-[(2-carboxyethyl)thio]-1,4-dihydroquinoline-3-carboxylic acid 9. The latter synthon is obtained by reduction of the 8-nitro-1,4-dihydroquinoline precursor 8 which, in turn, is made accessible via interaction of 3-mercaptopropionic acid with 7-chloro-1-cyclo...