Gamma-oryzanol merupakan senyawa antioksidan alami yang diperoleh dari minyak dedak padi atau lebih dikenal dengan rice bran oil (RBO). diketahui dapat melindungi kulit radiasi ultraviolet dan meningkatkan kelembaban kulit, sehingga dimanfaatkan sebagai antikerut pelembab di bidang kosmetik. Terdapat dua komponen penting menentukan sifat fisik emulgel, yaitu emulgator gelling agent. Penelitian ...

objective (s): mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.materials and methods:everydiscs containing 70 mg stem bark extract of ziziphus jujuba were formulated  by using carbopol 934, pvp k30 and gelatin as polymers. discs were made by granulation  and direct compression. discs were standardized based on the total phenol.  properties such as in vi...

Bawang Putih (Allium sativum L.) memiliki banyak manfaat bagi kesehatan tubuh, diantaranya sebagai antibakteri dan antifungi. putih antifungi masih digunakan secara tradisional, sehingga perlu dilakukan formulasi. Gel dipilih untuk formulasi bawang karena tidak lengket, stabil, mempunyai estetika yang bagus. Dalam gel ekstrak etanol diperlukan basis Na-CMC Carbopol menjaga stabilitas gel. Penel...

Aim: The aim of the work was to explore mucoadhesive properties Mastic gum by involving it in microspheres with Amoxicillin Trihydrate as a model drug. Using Carbopol-934P and varying amounts gum. Methods: 9 interpretations were made using Design expert software. A central composite design applied test impact independent variables (Carbopol-934P mastic levels) on drug released at 10h strength r...

The aim of our study was to develop a liposomal carrier system for the local treatment of bacterial vaginosis, capable to efficiently deliver entrapped drug during an extended period of time. Chloramphenicol was entrapped in liposomes composed of egg phosphatidylcholine/egg phosphatidylgycerol-sodium (9:1, molar ratio) and prepared by two different methods, the proliposome method and the polyol...

PURPOSE The purpose of this study was to develop and evaluate metronidazole loaded floating-mucoadhesive microsphere for sustained drug release at the gastric mucosa. METHODS Alginate gastroretentive microspheres containing metronidazole were prepared by ionic gelation method using sodium bicarbonate as gas forming agent, guar gum as mucoadhesive polymer, and Eudragit L100 as drug release mod...