The aims of this study were to prepare a thermosensitive composite hydrogel (TCH) by mixing 24% (w/v) poloxamer 407 (P407), 16% (w/v) poloxamer 188 (P188) and 0.1% (w/v) carbopol 940 (C940), and to determine the effect of natural borneol/ (2-hydroxypropyl)-β-cyclodextrin (NB/HP-β-CD) inclusion complex on the phase transition temperature, mechanical, rheological properties, and release behaviors...

Although the role of extracellular Ca(2+) draws increasing attention as a messenger in intercellular communications, there is currently no tool available for imaging Ca(2+) dynamics in extracellular regions. Here we report the first solid-state fluorescent Ca(2+) sensor that fulfills the essential requirements for realizing extracellular Ca(2+) imaging. Inspired by natural extracellular Ca(2+)-...

Pendahuluan: Sodium diklofenak merupakan obat golongan NSAID non selektif, yang memiliki koefisien partisi sebesar 13,4, sehingga penetrasinya melewati stratum korneum kurang optimal. Untuk itu diperlukan suatu bahan dapat membantu meningkatkan penetrasi ke dalam kulit yaitu enhancer. Tujuan: Penelitian ini bertujuan untuk melihat pengaruh penambahan mentol sebagai enhancer dengan kadar 0,5%, 0...

Poor bioavailability of ophthalmic drops is mainly due to drainage through the nasal-lacrimal duct and a very low permeability through corneal epithelium. The aim of our study was to prepare and characterize an ocular hydrogel of loratadine, as an example of a lipophilic drug, to increase drug concentration and residence time at the site of action in the eye. In this study,a 23full factorial de...

Hand sanitizer merupakan salah satu bahan antiseptik berupa gel yang sering digunakan masyarakat sebagai media pencuci tangan praktis. . Salah tanaman dapat obat tradisional adalah kulit Jeruk Bali (citrus maxima merr). Penelitian ini bertujuan untuk mengetahui adanya aktivitas didalam formula hand ekstrak etanol Bali. Proses ekstraksi dilakukan dengan maserasi menggunakan pelarut 70% dan dibua...

We present a study of microphase separation induced by competitive hydrogen bonding in A-b-B/C diblock copolymer/homopolymer complexes where the diblock copolymer A-b-B is immiscible and the homopolymer C can interact unequally with both A and B blocks through hydrogen bonding. A model system containing poly(2-vinyl pyridine)-block-poly(methyl methacrylate) (P2VP-b-PMMA) and poly(4-vinyl phenol...