نتایج جستجو برای: carbohydrate sulfotransferase 6 gene chst6

تعداد نتایج: 2014793  

Journal: :The Journal of biological chemistry 2012
Nobuo Sugiura Tatsumasa Shioiri Mie Chiba Takashi Sato Hisashi Narimatsu Koji Kimata Hideto Watanabe

Chondroitin sulfate (CS) is a linear acidic polysaccharide, composed of repeating disaccharide units of glucuronic acid and N-acetyl-D-galactosamine and modified with sulfate residues at different positions, which plays various roles in development and disease. Here, we chemo-enzymatically synthesized various CS species with defined lengths and defined sulfate compositions, from chondroitin hex...

2017
Hui Hong Markiyan Samborskyy Katsiaryna Usachova Katharina Schnatz Peter F Leadlay

Clethramycin from Streptomyces malaysiensis DSM4137, and mediomycins (produced together with clethramycin from Streptomyces mediocidicus), are near-identical giant linear polyenes apparently constructed from, respectively, a 4-guanidinobutanoate or 4-aminobutanoate starter unit and 27 polyketide extender units, and bearing a specific O-sulfonate modification at the C-29 hydroxy group. We show h...

2015
Chai-Ling Ho

Many algae are rich sources of sulfated polysaccharides with biological activities. The physicochemical/rheological properties and biological activities of sulfated polysaccharides are affected by the pattern and number of sulfate moieties. Sulfation of carbohydrates is catalyzed by carbohydrate sulfotransferases (CHSTs) while modification of sulfate moieties on sulfated polysaccharides was pre...

2013
SHIGERU HATABE HIDEHARU KIMURA TOKUZO ARAO HIROAKI KATO HIDETOSHI HAYASHI TOMOYUKI NAGAI KAZUKO MATSUMOTO MARCO DE VELASCO YOSHIHIKO FUJITA GO YAMANOUCHI MASAO FUKUSHIMA YASUHIDE YAMADA AKIHIKO ITO KIYOTAKA OKUNO KAZUTO NISHIO

The heparan sulfate sulfotransferase gene family catalyzes the transfer of sulfate groups to heparan sulfate and regulates various growth factor-receptor signaling pathways. However, the involvement of this gene family in cancer biology has not been elucidated. It was demonstrated that the heparan sulfate D-glucosaminyl 6-O-sulfotransferase-2 (HS6ST2) gene is overexpressed in colorectal cancer ...

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