AIM The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat. METHOD Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute inte...

P erforming cataract extraction in patients with zonular weakness presents many challenges and increases the risk of intraand postoperative complications. Capsular tension rings (CTRs) and other endocapsular support devices have been important management options for patients with significant zonulopathy. Hara et al1 and Nagamato and Bissen-Miyajima2 introduced the first endocapsular devices, bu...

BACKGROUND Complete removal of the cortex has been advocated to prevent posterior capsular opacification but carries the risk of zonular dehiscence, hence there is a need for a safe maximal cortical cleanup technique in eyes with severe diffuse zonulopathy in subjects above age 90. METHODS We used bimanual central cortical cleaning by elevating central fibers and aspirating them toward the pe...

BACKGROUND Capsule related complications are common following pediatric cataract surgery. We report a new technique of multiple anterior capsulorhexisotomies after lens aspiration and intraocular lens (IOL) implantation. METHODS After performing automated lens aspiration, an IOL was implanted into the capsular bag. A bent 26 gauge needle was introduced through one side port and multiple small...

A 44-year-old man with Down’s syndrome and neurogenic bladder which required a suprapubic catheter presented with fever and change in his urine color for one day. Physical examination revealed a temperature of 38.3°C, blood pressure of 60/30 mmHg, pulse rate of 120/min and urine with purple discoloration in the urine catheter and bag (Figure 1). A urine dipstick test indicated the presence of l...

A 67-year-old woman presented to the emergency department in congestive heart failure. She also had a history of transverse myelitis, which had caused her to be bedbound with an indwelling urinary catheter. During the physical examination, the urine in her Foley tubing and bag were noted to be bright purple. When asked, she replied that the urine had turned purple several weeks earlier. She den...

PURPOSE To study the role of TGF-beta2 in posterior capsule opacification (PCO) and to determine whether CAT-152 (lerdelimumab), a fully human monoclonal antibody that neutralizes the effect of TGF-beta2, can also provide therapeutic benefit for PCO. METHODS In vitro capsular bags were prepared from human donor eyes and maintained in a 5% CO(2) atmosphere at 35 degrees C. To investigate expre...

Postprandial hypotension occurs frequently and is associated with increased morbidity. Gastric distension may attenuate the postprandial fall in blood pressure (BP). Using a barostat, we sought to determine the effects of gastric distension on BP, heart rate (HR), and superior mesenteric artery (SMA) blood flow responses to intraduodenal glucose in eight (6 men, 2 women) healthy older (65-75 yr...