One major factor that heavily affects the performance of a content distribution network (CDN) is placement of the surrogates. Previous works take a network-centric approach and consider only the network traffic. In this paper, we propose solutions to optimal surrogate placement, taking into consideration both network latency and capacity constraints on the surrogates. For CDNs with a tree topol...

This is a computational study of bottlenecks on algebraic varieties. The smooth variety X ⊆ C n are the lines in which normal to at two distinct points. main result numerical homotopy that can be used approximate all isolated bottlenecks. has optimal number paths under certain genericity assumptions. In process we prove bounds terms Euclidean distance degree. Applications include optimization p...

Phase variation occurs in many pathogenic and commensal bacteria and is a major generator of genetic variability. A putative advantage of phase variation is to counter reductions in variability imposed by nonselective bottlenecks during transmission. Genomes of Campylobacter jejuni, a widespread food-borne pathogen, contain multiple phase-variable loci whose rapid, stochastic variation is gener...

The performance of a processor is limited by the specific bottlenecks that a benchmark exposes while running on that processor. Since the quantification of these bottlenecks can be extremely time-consuming, our prior work proposed using the Plackett and Burman design as a statistically-rigorous, but timeefficient method of determining the processor’s most significant performance bottlenecks. In...

Bottleneck-based scheduling is a popular approach in production scheduling, and it has achieved promising results in industry. To incorporate this approach in discrete event simulation tools is difficult since the approach requires multiple passes, forward and backward, to reach a good solution for the scheduling problem. In this paper, we propose a two-pass scheduling approach using discrete-e...