Porcine circovirus 2 (PCV2) strain 102 belongs to the PCV2b-1C subtype, and its sole structural protein (Cap) exhibits high homology with that of other PCV2b isolates reported in South Korea, China, and the United States. Strain 102 contains a new mutation (R37H) in the domain of the nuclear localization signal (NLS) of the Cap.

The genome sequence of a novel porcine circovirus 2 strain (CC12) is composed of 1,767 nucleotides, with two major open reading frames (ORFs). ORF1 encodes two replication-associated proteins (Rep and Rep') with the unique mutation N186S, and ORF2 encodes a viral capsid protein (Cap) with two rare mutations, R59K and A190T.

The origin of DNA replication of porcine circovirus (PCV) was mapped to a 111-bp fragment. On top of a hairpin, a nonanucleotide (TAGTATTAC) homologous to nonanucleotides of other viruses was identified. Mutation of this element abolishes replication. PCV may be related to a virus family characterized by single-stranded circular DNA genomes, rolling-circle replication, and homology of their rep...

Copyright ©NADIS 2017 Introduction Infection associated with Porcine Circovirus type 2 (PCV2) in pig herds, producing Post Weaning Multisystemic Wasting Disease (PMWS) and Porcine Dermatitis Nephropathy Syndrome (PDNS), appeared in the United Kingdom in the late 1990s and is now ubiquitous. Very few countries in the pig keeping world would claim to be free of the disease, although Australia may...

Porcine circovirus-like agent P1 is a newly discovered virus containing a single-strand circular genome. The genome of P1 is a DNA molecule of 648 nucleotides which contains eight open reading frames (ORFs) that probably encode potential proteins or polypeptides. Thus it is very important to clarify these proteins' function. Here we provide the methods and analysis of microarray data in detail ...

Four experiments were conducted to examine the effect of porcine circovirus type 2 (PCV2) vaccination on the response of growing and finishing pigs (PIC 337 × 1050) to increasing dietary Lys. Experiments 1 and 2 evaluated 38- to 65-kg gilts and barrows, respectively, and Exp. 3 and 4 evaluated 100- to 120-kg gilts and barrows, respectively. Gilts and barrows were housed separately in different ...

Porcine circovirus 2 (PCV2) is the primary etiological agent of postweaning multisystemic wasting syndrome (PMWS), one of the most economically important emerging swine diseases worldwide. Virulent PCV2 was first identified following nearly simultaneous outbreaks of PMWS in North America and Europe in the 1990s and has since achieved global distribution. However, the processes responsible for t...

This article describes the nucleotide sequence of a porcine circovirus (PCV) which possesses a high degree of association with postweaning multisystemic wasting syndrome (PMWS), a newly described disease of young pigs. The DNA sequence of this PMWS-associated PCV (pmws PCV) has 68% homology with that of a previously published nonpathogenic strain of PCV. The strains appear to be closely related...

Porcine circovirus type 2 (PCV2) is an economically important pathogen. It has been demonstrated that PCV2 DNA can be detected in boar semen by PCR; however, the biological relevance of this is unknown. The objectives of this study were to determine if semen positive for PCV2 DNA is infectious (1) in a swine bioassay, or (2) when used for artificial insemination. For the first objective, 4-week...