The aim of this ECVAM Status Seminar was to critically review the contributions made by ECVAM in relation to its four main task. The establishment and maintenance of the ECVAM Scientific Information Service (SIS) is a precise means of fulfilling one of these four principal duties of ECVAM. The major achievements of the SIS, and the efforts required to achieve them, are discussed, together with ...

In this paper we describe a Sequential Importance Sampling (SIS) procedure for counting the number of vertex covers in general graphs. The optimal SIS proposal distribution is the uniform over a suitably restricted set, but is not implementable. We will consider two proposal distributions as approximations to the optimal. Both proposals are based on randomization techniques. The first randomiza...

For most Global Positioning System (GPS) standard positioning service (SPS) users, real-time satellite orbits and clocks are derived from predicted ephemeris and clock parameters in broadcast navigation messages. Broadcast ephemeris and clock errors, the differences between the broadcast orbits/clocks and the truth, account for a dominant portion of signal-in-space (SIS) errors. Traditionally, ...

OBJECTIVE To examine the accuracy of clinical tests for diagnosing subacromial impingement syndrome (SIS). DATA SOURCES A systematic literature search was conducted in January 2011 to identify all studies that examined the diagnostic accuracy of clinical tests for SIS. The following search engines were used: Cochrane Library, EMBASE, Science Direct, and PubMed. STUDY SELECTION Two reviewers...

The mechanisms that control the periodicity of spontaneous epileptiform cortical potentials were investigated in the in vitro isolated guinea pig brain preparation. A brief intracortical application of bicuculline in the piriform cortex induced spontaneous interictal spikes (sISs) that recurred with high periodicity (8.5 +/- 3.1 sec, mean +/- SD). Intracellular recordings from principal neurons...

Resumo: O objetivo da pesquisa foi identificar e analisar os Sistemas de Informação em Saúde (SIS) base nacional que estiveram funcionamento no Brasil entre anos 2010 2018, assim como compreender a estrutura gestão suporte Tecnologia (TI) destes sistemas Ministério Saúde. É um estudo descritivo, baseado análise documental, se buscou consolidar dados sobre SIS abrangência com critérios seleção r...

Background: Abnormal uterine bleeding (AUB) can present with menorrhagia or metrorrhagia but cannot indicate the cause of bleeding, so further investigation is always needed. This study aimed to assess role Saline infusion sonography (SIS) in evaluating intracavitary lesions comparison transvaginal ultrasound (TVS) and thereby short listing patients for hysteroscopy.Methods: prospective analyti...

Human c-sis/PDGF-B proto-oncogene has been shown to be overexpressed in a large percentage of human tumor cells establishing a growth-promoting, autocrine growth circuit. Triplex forming oligonucleotides (TFOs) can recognize and bind sequences in duplex DNA, and have received considerable attention because of their potential for targeting specific genomic sites. The c-sis/PDGF-B promoter contai...