esophageal squamous cell carcinoma is a rather common cancer in northern iran. incidence of adenocarcinoma of esophagus has an increasing trend in iran. co-existence of both cancers in one patient is very rare. we report a middle age woman from northern iran with a typical presentation of esophageal cancer, who was found to have a dual esophageal cancer. the disease was found in the advanced st...

Colorectal carcinoma is one of the most common causes of cancer-related death, worldwide. Recently, due to the introduction of novel imaging and therapeutic techniques, five-year survival of patients has increased. However, distant metastasis is still expected in half of the patients. Colorectal cancer tends to target the abdominal cavity, liver, lungs, and bones as the common sites of metastas...

background: lung cancer is the most common cause of cancer death worldwide with an annual mortality rate of more than 1.3 million worldwide. we aimed to analyze the clinicopathological features of patients with non-small-cell lung cancer (nsclc) in west of iran. methods: 64 patients with nsclc who referred to our clinic were analyzed. sex, age, histopathology, location of the tumor, treatment, ...

Cancer metastasis is largely incurable and accounts for 90% of breast cancer deaths, especially the aggressive basal-like or triple negative (TNBC). Combining patient database analyses functional studies, we examined association integrin family members with clinical outcomes as well their connection previously identified microRNA regulators metastasis, such miR-206 that inhibits stemness TNBC. ...

objective(s): breast cancer is the most common type of cancer among women worldwide. this study investigated the expression and clinical significance of activating transcription factor 3 (atf3) in human breast cancer and its relationship with the clinical outcome of breast cancer.   materials and methods : atf3 expressions were detected in 114 primary breast cancer tissues and 114 adjacent norm...

Cancer causes most fatalities worldwide next only to cardiovascular disease. Early diagnosis helps reduce such incidences. In gastric cancer, abnormal expressions of micro ribonucleic acids (miRNAs) could serve as a marker. However, studies involving both miR-20a-5p and BRMS1L are limited. Here, we studied the acid (miR)-20a-5p its target gene breast cancer metastasis suppressor 1-like (BRMS1L)...

Background: Colorectal cancer (CRC) is currently the third leading cause for cancer-related mortality. Cancer stem cells have been implicated in colorectal tumor growth, but their specific role biology, including metastasis, still uncertain. Methods: Increased expression of L1CAM, CXCR4 and NODAL was identified section patients with CRC patients-derived-organoids (PDOs). The evaluated using qua...