نتایج جستجو برای: cancer dual targeting nanobody nrp
تعداد نتایج: 1169826 فیلتر نتایج به سال:
The discovery of naturally occurring, heavy-chain only antibodies in Camelidae, and their further development into small recombinant nanobodies, presents attractive alternatives in drug delivery and imaging. Easily expressed in microorganisms and amenable to engineering, nanobody derivatives are soluble, stable, versatile, and have unique refolding capacities, reduced aggregation tendencies, an...
The nuclear matrix is defined as the insoluble framework of the nucleus and has been implicated in the regulation of gene expression, the cell cycle, and nuclear structural integrity via linkage to intermediate filaments of the cytoskeleton. We have discovered a novel nuclear matrix protein, NRP/B (nuclear restricted protein/brain), which contains two major structural elements: a BTB domain-lik...
Here we review recombinant proteins with a capability for dual-targeting. These molecules address two different antigens on the same tumor cell and therefore are called “dual-targeting agents”. By virtue of binding a chosen pair of antigens on the malignant cell, preferential binding to antigen double-positive over single-positive cells can be achieved when both are present in the same environm...
Mycobacterium tuberculosis is responsible for nearly 2 million deaths yearly. Upon inhalation, mycobacteria are engulfed by alveolar macrophages. These cells produce reactive oxygen and nitrogen intermediates (ROI’s and RNI’s), which normally kill pathogens, but are ineffective against invading mycobacteria. What ensues, is the formation of a tubercle to sequester the infected macrophages, and ...
Malignant gliomas are among the rarest brain tumours, and they have the worst prognosis. Grade IV astrocytoma, known as glioblastoma multiforme (GBM), is a highly lethal disease where the standard therapies of surgery, followed by radiation and chemotherapy, cannot significantly prolong the life expectancy of the patients. Tumour recurrence shows more aggressive form compared to the primary tum...
OBJECTIVE Neuropilin-1 (NRP-1) is a multidomain membrane receptor involved in angiogenesis and development of neuronal circuits, however, the role of NRP-1 in cardiovascular pathophysiology remains elusive. APPROACH AND RESULTS In this study, we first observed that deletion of NRP-1 induced peroxisome proliferator-activated receptor γ coactivator 1α in cardiomyocytes and vascular smooth muscl...
Nanomedicines In article 2201140 by Hsin-Cheng Chiu and co-workers, an oral polysaccharide microgel formulation containing dual-modality therapeutic nanoparticles developed for local treatment of colon cancer is imparted to hierarchical targeting residues, leading increases in retention cell uptake nanotherapeutics. With enzymatic degradation dextran microgels occurring exclusively the colon, n...
CD47 is a ubiquitously expressed immune checkpoint receptor that is often upregulated in cancer. CD47 interacts with its counter-receptor SIRPα on macrophages and other myeloid cells to inhibit cancer cell phagocytosis and drive immune evasion. To overcome tolerability and "antigen sink" issues arising from widespread CD47 expression, we generated dual-targeting bispecific antibodies that selec...
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