Background: Drug nano-carriers are one of the most important tools for targeted cancer therapy so that undesired side effects of chemotherapy drugs are minimized. In this area, the use of ultrasound can be helpful in controlling drug release from nanoparticles to achieve higher treatment efficiency.Objective: Here, we studies the effects of ultrasound irradiation on the release profile of 5-flu...

One of the challenges nanotechnology is to improve efficacy treatments for diseases, in order reduce morbidity and mortality rates. Following this line study, we made a nanoparticle formulation with small size, uniform surfaces, satisfactory encapsulation coefficient as target colorectal cancer cells. The results binding uptake prove that using system folic acid works: Using system, cytotoxicit...

Standard treatment for colorectal cancer includes surgery, radiotherapy, and chemotherapy. Conventional chemotherapeutic agents used in such as 5-fluorouracil, capecitabine which is oral form of irinotecan, oxaliplatin. One the major challenges chemotherapy considered drug resistance. Drug resistance occurs many different mechanisms alteration tumor microenvironment, growth kinetics, genetic va...

One of the most important challenges in fight against cancer is acquired drug resistance. P-glycoprotein (P-gp), encoded by ABCB1 gene many organs, one factors involved development P-gp mainly efflux toxic substances such as xenobiotics from cell. In addition to these, it also plays a role drugs used treatment cancer, rate success reduces. Phenolic compounds are chemicals that naturally synthes...

cancer stem cells (cscs) have been identified as rare cellular populations in many cancers, including leukemia and solid tumors. this minor subpopulation of cancerous cells is immortal tumor-initiating cells which thought to be responsible for cancer initiation, progression, metastasis, recurrence and drug/radiation resistance. low proliferative rate, high self-renewing capacity, differentiatio...

Physical drug delivery through smart nanocarrier and external stimulus could lead to significant improvements of drug potency as well as noticeable decrease in unwanted side effects. Currently, many external energy sources such as light, magnetic fields, ultrasound, ...,  are under investigation as external stimulus for physical drug delivery. The purpose of this paper is to review most recent ...