Restriction of calorie intake from the time of weaning greatly prolongs life, and it inhibits development and expression of the lymphoproliferative syndrome, renal disease, and decline of certain immunologic functions with age in MRL/lpr mice. This dramatic influence of diet on mice of this short-lived autoimmunity-prone strain, while associated with decreased rate of growth, is not associated ...

Epigenetic inheritance of resistance to exogenous nucleic acids via small interfering (si) RNA is well established in animal models. Rechavi et al. demonstrate epigenetic inheritance of a starvation-induced pattern of gene silencing caused by endogenous siRNAs and resulting in an increased longevity in the third generation progeny. Combined with recent findings in prokaryotes, these results sug...

OBJECTIVE: Obesity is a worldwide health problem, with increasing prevalence associated with an increased risk of chronic diseases. Decrease in energy intake has been shown to lower the risk of coronary artery disease (CAD) in obese. The common form of dietary restriction is daily calorie restriction (CR). Another form is alternate-day fasting (ADF). The ability of modified ADF to facilitate we...

Dietary restriction (DR) is a valuable experimental tool for studying the aging process. Primary advancement of research in this area has relied on rodent models, but attention has recently turned toward Drosophila melanogaster. However, little is known about the baseline effects of DR on wild-type Drosophila and continued experimentation requires such information. The findings described here s...

The elderly population increases and more prolonged life expectancy increased worldwide, with this increase, healthy aging gained importance. of a longer healthier has created curiosity about how nutrition can be. Nutrition is one the critical factors for aging. Some diet models applications (for example, calorie restriction) extend quality span life. Life in some places globally (Blue Zones, H...

AIMS To establish whether an 8-week very-low-calorie diet could improve glycaemic control in Type 2 diabetes of long duration. METHODS A total of 29 people with Type 2 diabetes [short-duration group (diabetes duration < 4 years), n = 15; long-duration group (diabetes duration > 8 years), n = 14] completed an 8-week very-low-calorie diet, with assessments of fasting anthropometry, blood tests ...

Introduction: Obesity is now becoming a growing problem and challenge for medicine. The number of people with excessive body weight has reached more than 2 billion, or about 30% the world's population. purpose this article to identify describe some already known treatments obesity, along latest research on subject, in order show importance developing introducing new methods loss.Aim study: revi...