PURPOSE Hepatocellular carcinoma (HCC) is a rapidly growing tumor associated with a high propensity for vascular invasion and metastasis. Epithelial-mesenchymal transition (EMT) is a key event in the tumor invasion process. Recently, Twist has been identified to play an important role in EMT-mediated metastasis through the regulation of E-cadherin expression. However, the actual role of Twist i...

Aberrant epidermal growth factor receptor (EGFR) signaling is a major cause of tumor progression and metastasis; the underlying mechanisms, however, are not well understood. In particular, it remains elusive whether deregulated EGFR pathway is involved in epithelial-mesenchymal transition (EMT), an early event that occurs during metastasis of cancers of an epithelial origin. Here, we show that ...

Before discussing the pathogenesis and clinical aspects of this disease, clarification of some of the pertinent terminological definitions may be in order. Hypertrophic emphysema is the most commonly used designation of this disease. Also, it is known under the following names: genuine emphysema, idiopathic emphysema, diffuse vesicular emphysema, obstructive emphysema, dystrophlc emphysema, pul...

Our question answering system was built with a number of priorities in mind. First, we wanted to experiment with natural language processing (NLP) technologies such as shallow parsing, named entity tagging, and coreference chaining. We felt that the small number of terms in the questions coupled with the short length of the answers would make NLP technologies clearly beneficial, unlike previous...

2 Principal contact: This year our primary goal was to improve on the performance of our TREC-8 system. In addition to improving the system directly, we worked on a number of tools to aid our development. We continued our work on a tool for automatic scoring of system responses, a “judge” program. We designed a tool for doing regression testing of question answering systems. W...

Loss of estrogen receptor α (ERα) expression and gain of TWIST (TWIST1) expression in breast tumors correlate with increased disease recurrence and metastasis and poor disease-free survival. However, the molecular and functional regulatory relationship between TWIST and ERα are unclear. In this study, we found TWIST was associated with a chromatin region in intron 7 of the human ESR1 gene codin...

We present a derivation of Wandzura-Wilczek (WW) like relations for skewed parton distributions. It is demonstrated for photon-pion scattering that for transverse photon polarization the skewed twist-3 parton distributions contributing to the DVCS amplitude have discontinuities at the points x = ±ξ in the WW approximation. Unless these discontinuities are cancelled by the neglected genuine high...