Inhibition of whole-cell calcium currents in enzymatically dispersed frog atrial myocytes by D-600, diltiazem, and nifedipine was studied using a single-micropipette voltage-clamp technique. The objective of these experiments was to test the applicability of a modulated-receptor hypothesis similar to that proposed for local anesthetic interactions with sodium channels to account for the tonic a...

Halocarbons (CCl4, 1,1-dichlorethylene) cause a wide spectrum of effects and injury in hepatocytes. One early effect of these compounds is the inhibition and destruction of the endoplasmic reticulum (ER) calcium pump. Subsequent to inhibition of this pump, the ER calcium pool is depleted and cytosolic levels of calcium are increased for a prolonged period of time. This effect of halocarbons has...

During the early stages of development, the embryo depends on the placenta as provider of oxygen and calcium, among other essential compounds. Although fetal liver accomplishes a well-known haematopoietic function, its contribution to calcium homeostasis upon development is poorly understood. The homeostasis of cell calcium contributes to diverse signaling pathways across developmental stages o...

Calcium and magnesium are essential for survival but it is unknown how animals detect and consume enough of these minerals to meet their needs. To investigate this, we exploited the PWK/PhJ (PWK) strain of mice, which, in contrast to the C57BL/6J (B6) and other inbred strains, displays strong preferences for calcium solutions. We found that the PWK strain also has strong preferences for MgCl2 a...

Uranium is one of the most studied actinoids, widely used in nuclear industry, and can accumulate drinking water, soil, plants, calcium-containing body tissues. The purpose work was to investigate presence uranium isotopes U-235 U-238 composition kidney stones patients with urolithiasis living Kharkiv region. content investigated samples obtained as a result minimally invasive surgical interven...

The enormous role of water in the life all living beings, including humans, is due to fact that it a universal solvent for huge number chemicals. Water was one first compounds attract attention scientists, yet its study still incomplete. basis and raw material technologies industries. used technological process food industry must comply with hygienic requirements and, addition cleaning, reducin...