Research Framework Spatial abilities are fundamental to human functioning in the physical world. Spatial reasoning allows people to use concepts of shape, features, and relationships in both concrete and abstract ways, to make and use things in the world, to navigate, and to communicate (Cohen, Hegarty, Keehner & Montello, 2003; Newcombe & Huttenlocher, 2000; Turos & Ervin, 2000). Visualizing i...

Cleft lip with or without cleft palate (CL/P) and only (CPO) are congenital birth defects where the upper and/or fail to fuse properly during embryonic facial development. CL/P CPO fall under larger category of orofacial clefts (OFCs), which affect ~1.2/1000 live births world-wide imposes significant social financial burdens on affected individuals their families. The etiology is complex likely...

In-silico Computer-Aided Drug Design (CADD) significantly relies on cybernetic screening of Plant Based Natural Products (PBNPs) as a prime source bioactive compounds/ drug leads due to their unique chemical structural scaffolds and distinct functional characteristic features amenable design development. In the Post-COVID-Era large number publications have focused PBNPs. Moreover, PBNPs still r...

Molecular docking is a modeling tool of Bioinformatics which includes two or more molecules interact to provide stable product in the form complex. helpful predicting 3-d structure complex depends on binding characteristics Ligand and target. Also, it structure-based virtual screening (SBVS) utilized keep structures small molecule are generated by computers into target various types conformatio...

Although there is clear evidence that low verbal ability is a risk factor for conduct disorder (CD), some researchers have questioned whether this association is due to the common comorbidity between attention-deficit/hyperactivity disorder (ADHD) and CD. The present study examined the association among verbal ability, ADHD, and CD in a genetically informative sample in order to examine the rol...

Accurate deleteriousness prediction for nonsynonymous variants is crucial for distinguishing pathogenic mutations from background polymorphisms in whole exome sequencing (WES) studies. Although many deleteriousness prediction methods have been developed, their prediction results are sometimes inconsistent with each other and their relative merits are still unclear in practical applications. To ...

Abstract:Cancer is the 2 leading cause of death in humans. Proteine.g. tyrosine kinaseleads to cancer when become constitutively active due to mutation. So there is a need to develop tyrosine kinase inhibitors to avoid cancer.In the present study the problem of designing an anticancer drug with more efficacies was solved by using computer aided drug designing (CADD). Antioxidants were used as t...

Genome-wide association studies (GWASs) for many complex diseases, including inflammatory bowel disease (IBD), produced hundreds of disease-associated loci-the majority of which are noncoding. The number of GWAS loci is increasing very rapidly, but the process of translating single nucleotide polymorphisms (SNPs) from these loci to genomic medicine is lagging. In this study, we investigated 4,7...