نتایج جستجو برای: caco 2 cell

تعداد نتایج: 3839619  

Journal: :Microbiology 2005
Amanda MacCallum Simon P Hardy Paul H Everest

Caco-2 cells are models of absorptive enterocytes. The net transport of fluid from apical to basolateral surfaces results in 'domes' forming in differentiated monolayers. Here, the effect of Campylobacter jejuni on this process has been examined. C. jejuni caused no changes in short-circuit current upon infection of Caco-2 cell monolayers in Ussing chambers. Thus, no active secretory events cou...

2013
Paul Dean Lorna Young Sabine Quitard Brendan Kenny

Enteropathogenic E. coli (EPEC) is a human pathogen that targets the small intestine, causing severe and often fatal diarrhoea in infants. A defining feature of EPEC disease is the loss (effacement) of absorptive microvilli (MV) from the surface of small intestinal enterocytes. Much of our understanding of EPEC pathogenesis is derived from studies using cell lines such as Caco-2 - the most exte...

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008
Yoshihiko Hirotani Kenji Ikeda Ryuji Kato Michiaki Myotoku Takashi Umeda Yoshio Ijiri Kazuhiko Tanaka

Indirect evidence suggests that lactoferrin (Lf), a major iron-binding protein in human milk, induces enterocyte growth and proliferation, depending on its concentration and affects the function and permeability of the intestinal mucosa. The bacterial endotoxin (lipopolysaccharide, LPS) is known to cause mucosal hyperpermeability in vivo. However, protective effects of Lf against LPS-mediated i...

Journal: :Acta biochimica Polonica 2007
Davy Vanden Broeck Albert R Lagrou Marc Js De Wolf

The involvement of the clathrin-mediated endocytic internalization route in the uptake of cholera toxin (CT) was investigated using different cell lines, including the human intestinal Caco-2 and T84 cell lines, green monkey Vero cells, SH-SY5Y neuroblastoma cells and Madin-Darby canine kidney cells. Suppression of the clathrin-mediated endocytic pathway by classical biochemical procedures, lik...

Journal: :Cancer research 1998
P O Beaumont M J Moore K Ahmad M M Payne C Lee D S Riddick

The anthracycline doxorubicin has little activity against colorectal cancers. It is hypothesized that this is attributable to a multifactorial resistance mechanism in which the glutathione S-transferases (GST) may play a role. We studied the relationship between GST expression and doxorubicin resistance in four human colon adenocarcinoma cell lines (HT-29, LoVo, SW620, and Caco-2), with the goa...

Journal: :Bioscience, biotechnology, and biochemistry 2008
Nozomi Hisada Hideo Satsu Akira Mori Mamoru Totsuka Jun-ichi Kamei Takashi Nozawa Makoto Shimizu

The intestinal permeability of low-molecular-weight hyaluronan (LMW-HA) was investigated by using cultured monolayers of Caco-2 cells. The amount of LMW-HA that permeated the Caco-2 monolayers was measured by a carbazole assay. The permeability of LMW-HA increased inversely with the molecular size and was dose-dependent. The transport was observed to be energy-independent, and was correlated wi...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2004
Matthew A Sanders Marc D Basson

Our previous work indicates intestinal epithelial cell ERK activation by collagen IV, a major component of the intestinal epithelial basement membrane, requires focal adhesion kinase (FAK) and suggests FAK and ERK may have important roles in regulating intestinal epithelial cell migration. We therefore sought to identify FAK downstream targets regulating intestinal epithelial cell spreading, mi...

2016
Henrike Peuschel Thomas Ruckelshausen Silke Kiefer Yuliya Silina Annette Kraegeloh

BACKGROUND Quantum dots (QDs) have great potential as fluorescent labels but cytotoxicity relating to extra- and intracellular degradation in biological systems has to be addressed prior to biomedical applications. In this study, human intestinal cells (Caco-2) grown on transwell membranes were used to study penetration depth, intracellular localization, translocation and cytotoxicity of CdSe/Z...

2006
Marina Di Domenico Gabriella Castoria Antonio Bilancio Antimo Migliaccio Ferdinando Auricchio

This is the first report on estrogen-dependent growth of human-derived colon carcinoma cells. Under selected conditions, growth of suhconfluent Caco-2 cells is triggered by estradiol. Cell growth is estradiol concentra tion dependent, with maximal effect occurring ut uhout 0.4 n\i. ( i row lit is prevented by two différentantiestrogens: the partial agonist, OH-Tamoxifen, and the pure antagonis...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید