نتایج جستجو برای: ca2 i increases

تعداد نتایج: 1386585  

Journal: :Hypertension 1998
Z Ni X Q Wang N D Vaziri

Long-term administration of erythropoietin (EPO) frequently causes hypertension in humans and animals with chronic renal failure (CRF). We recently demonstrated that EPO-induced hypertension is hematocrit independent and accompanied by elevated cytosolic [Ca2+]i and nitric oxide (NO) resistance. This study was undertaken to examine the effects of therapy with EPO alone or together with calcium ...

Journal: :Brain research 1998
M Anderova A D Duchêne J G Barbara K Takeda

The actions of vasoactive intestinal polypeptide (VIP) on catecholamine secretion and changes in [Ca2+]i in single rat chromaffin cells were studied using amperometry and Indo-1. Application of VIP prior to acetylcholine (ACh) or co-application of VIP and ACh enhanced secretion by 94% and 153% respectively, compared to ACh alone. [Ca2+]i was increased by 17% when VIP was preapplied and by 73% u...

Journal: :The Journal of Cell Biology 1998
P. Lorenzon E. Vecile E. Nardon E. Ferrero J.M. Harlan F. Tedesco A. Dobrina

Previous studies have shown that polymorphonuclear leukocyte (PMN) adherence to endothelial cells (EC) induces transient increases in EC cytosolic free calcium concentration ([Ca2+]i) that are required for PMN transit across the EC barrier (Huang, A.J., J.E. Manning, T. M. Bandak, M.C. Ratau, K.R. Hanser, and S.C. Silverstein. 1993. J. Cell Biol. 120:1371-1380). To determine whether stimulation...

Journal: :The Journal of biological chemistry 1992
D Kline J T Kline

At fertilization, the sperm initiates development of the mouse egg by inducing a large transient increase in the intracellular Ca2+ concentration ([Ca2+]i), which is followed by repetitive transient increases in [Ca2+]i. To determine how the repetitive Ca2+ transients are produced, thapsigargin, an inhibitor of the endoplasmic reticulum Ca-ATPase, was used to deplete intracellular Ca2+ stores w...

Journal: :Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 2005
Soichi Miwa Yoshifumi Kawanabe Yasuo Okamoto Tomoo Masaki

Endothelin-1 (ET-1) is a 21-amino-acid peptide and it is one of the most potent endogenous vasoconstricting agent yet discovered (Yanagisawa et al., 1988). ET-1 binds to its receptors (typically ETA receptor) on vascular smooth muscle cells (VSMCs) and subsequently induces an increase in the intracellular free Ca2+ concentration ([Ca]i), which is essential for contraction of the cells. It is ge...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2002
Sam X Cheng Masahiro Okuda Amy E Hall John P Geibel Steven C Hebert

The calcium-sensing receptor (CaSR) is activated by extracellular calcium (Ca2+(o)) and mediates many of the known effects of extracellular divalent minerals on body cells. Both surface and crypt cells express CaSR transcripts and protein on both apical and basolateral surfaces. Raising Ca2+(o) elicited increases in intracellular calcium (Ca2+(o)) in both surface and crypt cells with an EC50 of...

Journal: :The Journal of biological chemistry 2003
Ronit Lavi Asher Shainberg Harry Friedmann Vladimir Shneyvays Ophra Rickover Maor Eichler Doron Kaplan Rachel Lubart

Low energy visible light (LEVL) irradiation has been shown to exert some beneficial effects on various cell cultures. For example, it increases the fertilizing capability of sperm cells, promotes cell proliferation, induces sprouting of neurons, and more. To learn about the mechanism of photobiostimulation, we studied the relationship between increased intracellular calcium ([Ca2+]i) and reacti...

Journal: :The Journal of General Physiology 2000
Stephen L. Colegrove Meredith A. Albrecht David D. Friel

We studied how mitochondrial Ca2+ transport influences [Ca2+](i) dynamics in sympathetic neurons. Cells were treated with thapsigargin to inhibit Ca2+ accumulation by SERCA pumps and depolarized to elevate [Ca2+(i); the recovery that followed repolarization was then examined. The total Ca2+ flux responsible for the [Ca2+](i) recovery was separated into mitochondrial and nonmitochondrial compone...

Journal: :The Biochemical journal 1994
I F Musgrave R Seifert G Schultz

We investigated whether maitotoxin activates non-selective cation channels, as was recently proposed [Soergel, Yasumoto, Daly and Gusovsky (1992) Mol. Pharmacol. 41, 487-493]. Stimulation of dibutyryl cyclic AMP-differentiated HL-60 cells with the chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; 0.1 microM), the Ca(2+)-ATPase inhibitor thapsigargin (0.1 microM) or maitot...

Journal: :The Journal of General Physiology 2003
Carla M. Pedrosa Ribeiro Anthony M. Paradiso Alessandra Livraghi Richard C. Boucher

In airway epithelia, purinergic receptor (P2Y2-R) stimulation of intracellular calcium (Ca2+i)-regulated ion transport is restricted to the membrane domain ipsilateral to receptor activation, implying compartmentalization of Ca2+i signaling. Because mitochondria can spatially restrict cellular Ca2+i signals, immunocytochemical, electron microscopic, and fluorescent studies of mitochondria local...

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