AimsUpregulation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) contributes to the pathogenesis cardiovascular disease, including hypertension. Transgenic rats expressing human angiotensinogen gene [TGR (hAGT)L1623] are a new novel humanized model hypertension that associates with declines in cardiac contractile function and β-adrenergic receptor (AR) reserve. The molecular mechanisms ...

Both risperidone, an atypical antipsychotic drug, and functionbased behavior-analytic interventions are popular and empirically validated treatments for reducing challenging behavior in children with autism. The kind of research that supports their effectiveness differs, however, and no published study has directly compared their effects or examined the two in combination. The research methods ...

This study evaluated the success rates of 50 full-arch maxillary and/or mandibular implant-supported fixed complete dentures. After a mean follow-up time of 42.1 months, 269 implants remained in function, which corresponded to cumulative implant success rates of 85.2% and an absolute success rate of 90.6% (269/297 implants). This study suggested that higher implant failure rates might be associ...

objective(s): thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring.  considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. materials and methods: hypothyroidism was induced in female rats by administ...

Revealing the binding properties of calcium ion (Ca2+) and magnesium (Mg2+) to terrestrial chromophoric dissolved organic matter (CDOM) facilities understanding effect natural water components on photophysics matter. Steady-state time-resolved fluorescence spectrometry, dynamic light scattering were applied investigate quenching process CDOM by Ca2+ Mg2+. Due a remarkable decrease steady-state ...

Depressed contractility is a central feature of the failing human heart and has been attributed to altered [Ca2+]i. This study examined the respective roles of the L-type Ca2+ current (ICa), SR Ca2+ uptake, storage and release, Ca2+ transport via the Na+-Ca2+ exchanger (NCX), and Ca2+ buffering in the altered Ca2+ transients of failing human ventricular myocytes. Electrophysiological techniques...

Cardiac alternans are thought to be a precursor to life-threatening arrhythmias. Previous studies suggested that alterations in sarcoplasmic reticulum (SR) Ca2+ content are either causative or not associated with myocyte Ca2+ alternans. However, those studies used indirect measures of SR Ca2+. Here we used direct continuous measurement of intra-SR free [Ca2+] ([Ca2+]SR) (using Fluo5N) during fr...