This paper presents a comparative study about the evaluation of antioxidant activity and corrosion inhibition in Kenitra, Marrakesh Taiz. An interesting topic, indeed polyphenols can improve or help to reduce oxidative stress treatment digestive problems, weight management difficulties, diabetes, hypertension, arteriosclerosis damage fatty tissue. Therefore, authors deal with measurement polyph...

The effect of structural modifications of okadaic acid (OA), a polyether C38 fatty acid, was studied on its inhibitory activity toward type 1 and type 2A protein phosphatases (PP1 and PP2A) by using OA derivatives obtained either by isolation from natural sources or by chemical processes. The dissociation constant (Ki) for the interaction of OA with PP2A was estimated to be 30 (26-33) nM [media...

Cystic fibrosis (CF), a multisystem disease caused by CFTR (cystic fibrosis transmembrane conductance regulator) gene mutations, is associated with an abnormal inflammatory response and compromised redox homeostasis in the airways. Recent evidence suggests that dysfunctional CFTR leads to redox imbalance and to mitochondrial reduced glutathione (mtGSH) depletion in CF models. This study was des...

The microbial community response to petroleum seepage was investigated in a whole round sediment core (16 cm length) collected nearby natural hydrocarbon seepage structures in the Caspian Sea, using a newly developed Sediment-Oil-Flow-Through (SOFT) system. Distinct redox zones established and migrated vertically in the core during the 190 days-long simulated petroleum seepage. Methanogenic pet...

recurr moso spann the N tified (10 p gain). each o 2 case sampl reduc hetero of 10 NF1 e numb NF1 e NF protei impor Activa appro cytic leuke mato have marke ing m sine p presen activa his issue of Clinical Cancer Research, Parkin and gues report on the identification of a subset of adult myelogenous leukemia (AML), in which the tumor essor NF1 is functionally inactive, resulting in ind Ras sign...

Two highly potent and selective cystic fibrosis (CF) transmembrane regulator (CFTR) inhibitors have been identified by high-throughput screening: the thiazolidinone CFTR(inh)-172 [3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]- 2-thioxo-4-thiazolidinone] and the glycine hydrazide GlyH-101 [N-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide]. Inhibitio...

This paper provides a novel mechanism for identifying and estimating latent group structures in panel data using penalized regression techniques. We focus on linear models where the slope parameters are heterogeneous across groups but homogenous within a group and the group membership is unknown. Two approaches are considered — penalized least squares (PLS) for models without endogenous regress...

recurr moso spann the N tified (10 p gain). each o 2 case sampl reduc hetero of 10 NF1 e numb NF1 e NF protei impor Activa appro cytic leuke mato have marke ing m sine p presen activa his issue of Clinical Cancer Research, Parkin and gues report on the identification of a subset of adult myelogenous leukemia (AML), in which the tumor essor NF1 is functionally inactive, resulting in ind Ras sign...

Purpose: Taxanes are important chemotherapeutic agents with proven efficacy in human cancers, but their use is limited by resistance development. We report here the preclinical characteristics of cabazitaxel (XRP6258), a semisynthetic taxane developed to overcome taxane resistance. Experimental Design:Cabazitaxel effects on purified tubulin and on taxane-sensitive or chemotherapyresistant tumor...

PURPOSE Taxanes are important chemotherapeutic agents with proven efficacy in human cancers, but their use is limited by resistance development. We report here the preclinical characteristics of cabazitaxel (XRP6258), a semisynthetic taxane developed to overcome taxane resistance. EXPERIMENTAL DESIGN Cabazitaxel effects on purified tubulin and on taxane-sensitive or chemotherapy-resistant tum...