Abstract Background The imposition of containment measures internationally during the first wave Covid-19 pandemic has indicated need for data on psychological impact quarantine. We use C19 ISWS Greek dataset to examine self-reported depression in relation alcohol and tobacco use, social contacts, relationship status perceived risk infection. Methods Online survey was collected between May-June...

The mechanism of inhibition of estrogen synthetase (P-450arom) by 19R- and 19S-isomers of 10-oxiranyl-and 10-thiiranyl-4-estrene-3,17-dione was investigated using human placental microsomes and purified enzyme preparations. The 19R-isomers were potent inhibitors and exhibited affinities 36-fold (10-oxirane) and 80-fold (10-thiirane) greater than the respective 19S-isomers. Kinetic experiments s...

Induced pluripotent stem cells (iPSC) are an attractive progenitor source for the generation of in vitro blood products. However, before iPSC-derived erythroid cells can be considered for therapeutic use their similarity to adult erythroid cells must be confirmed. We have analysed the proteome of erythroid cells differentiated from the iPSC fibroblast derived line (C19) and showed they express ...

Two studies have recently shown a clear benefit of using nonsteroidal aromatase inhibitors (AIs) in combination with growth hormone (rhGH) in pubertal boys of very short stature (between -2.5 and 3 SDS) who are approaching the end of their growth [1,2]. AIs have been used in human therapeutics since the 1990s, mostly in adults [3], to block aromatase by binding to the heme iron of aromatase, a ...

A stereoselective synthesis of (+)-norrisolide is presented. This natural product belongs to a family of marine spongiane diterpenes the structure of which is characterized by a fused gamma-lactone-gamma-lactol ring system attached to a bicyclic hydrophobic core. Our studies led to the development of a expedient synthesis of such gamma-lactone-gamma-lactol motifs based on ring expansion of a fu...

Salinomycin is a widely used polyether coccidiostat and was recently found to have antitumor activities. However, the mechanism of its biosynthesis remained largely speculative until now. Reported herein is the identification of an unprecedented function of SlnM, homologous to O-methyltransferases, by correlating its activity with the formation of the Δ(18,19) double bond and bis(spiroacetal). ...

An n-hexane extract of fresh, mature leaves of Argemone mexicana (Papaveraceae), containing thin-layer epicuticular waxes, has been analysed for the first time by TLC, IR and GLC using standard hydrocarbons. Seventeen long-chain alkanes (n-C18 to n-C34) were identified and quantified. Nonacosane (n-C29) was established as the n-alkane with the highest amount, whilst octadecane (n-C19) was the l...

This paper presents an empirical estimation of a catastrophe model of organizational adoptions of a high technology product when network externalities are present. As such, it integrates work from the economics literature and the catastrophe literature to provide a broader look adoptions issues. Additionally, it is one of the few empirical studies we are aware of that attempt to model organizat...