There is a growing interest in the potential anxiolytic- and antidepressant-like effects of compounds that target neurokinin receptors. Since the structure and the pharmacology of the human neurokinin receptor resembles that of gerbils, rather than that of mice or rats, we decided to investigate the anxiolytic- and /or antidepressant-like effects of NK1 (SSR240600), NK2 (saredutant) and NK3 (os...

the aim of the current study was to design a porous osmotic pump–based drug delivery system for controlling the release of buspirone from the delivery system. the osmotic pump was successfully developed using symmetric membrane coating. the core of the tablets was prepared by direct compression technique and coated using dip-coating technique. drug release from the osmotic system was studied us...

RATIONALE The serotonergic and cholinergic systems are jointly involved in regulating sleep but this system is theorized to be disturbed in depressed individuals. We previously reported that cholinergic and serotonergic agents induce sleep changes partially consistent with monoamine models of sleep disturbances in depression. One potential cause of disturbed neurotransmission is genetic predisp...