To assess the budget impact of adding an HIV pre-exposure prophylaxis (PrEP) telemedicine intervention (telePrEP) in Mississippi, a state with one highest rates US. We developed Markov model and PrEP use Mississippi among two eligible populations: 1) men who have sex (MSM) 2) heterosexually active individuals age ≥16 years indications for as per US Centers Disease Control guidelines. The utiliz...