نتایج جستجو برای: btk expression

تعداد نتایج: 873168  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Lee A Honigberg Ashley M Smith Mint Sirisawad Erik Verner David Loury Betty Chang Shyr Li Zhengying Pan Douglas H Thamm Richard A Miller Joseph J Buggy

Activation of the B-cell antigen receptor (BCR) signaling pathway contributes to the initiation and maintenance of B-cell malignancies and autoimmune diseases. The Bruton tyrosine kinase (Btk) is specifically required for BCR signaling as demonstrated by human and mouse mutations that disrupt Btk function and prevent B-cell maturation at steps that require a functional BCR pathway. Herein we de...

Journal: :Blood 2014
Stuart A Rushworth Megan Y Murray Lyubov Zaitseva Kristian M Bowles David J MacEwan

Bruton's tyrosine kinase (BTK) is a cytoplasmic protein found in all hematopoietic cell lineages except for T cells. BTK mediates signaling downstream of a number of receptors. Pharmacologic targeting of BTK using ibrutinib (previously PCI-32765) has recently shown encouraging clinical activity in a range of lymphoid malignancies. This study reports for the first time that ibrutinib inhibits bl...

2007
Sarah L. Doyle Caroline A. Jefferies Con Feighery Luke A. J. O’Neill

Toll-like receptors (TLRs) are a primary surveillance system for the detectionof pathogens and are crucial to the activationof host defense. TLR7 and TLR8 sense single-stranded RNA from viruses or host ribonucleoproteins and synthetic imidazoquinolines such as R848, whereas TLR9 senses unmethylated CpG motifs in viral and bacterial DNA and in host DNA. Here we report the endogenous interaction ...

Journal: :The Journal of Experimental Medicine 1996
M Takata T Kurosaki

Defects in the gene encoding Bruton's tyrosine kinase (Btk) result in a disease called X-linked agammaglobulinemia, in which there is a profound decrease of mature B cells due to a block in B cell development. Recent studies have shown that Btk is tyrosine phosphorylated and activated upon B cell antigen receptor (BCR) stimulation. To elucidate the functions of this kinase, we examined BCR sign...

Journal: :Histology and histopathology 2005
C Brunner B Müller T Wirth

Btk is a cytoplasmic tyrosine kinase, which is mainly involved in B cell receptor signalling. Gene targeting experiments revealed that Btk is important for B cell development and function. However, Btk is not only expressed in B cells, but also in most other haematopoietic lineages except for T cells and plasma cells. Recently we found that Btk is involved in Toll-like receptor signalling. Toll...

2014
Hong Wu Wenchao Wang Feiyang Liu Ellen L. Weisberg Bei Tian Yongfei Chen Binhua Li Aoli Wang Beilei Wang Zheng Zhao Douglas W. McMillin Chen Hu Hong Li Jinhua Wang Yanke Liang Sara J. Buhrlage Junting Liang Jing Liu Guang Yang Jennifer R. Brown Steven P. Treon Constantine S. Mitsiades James D. Griffin Qingsong Liu Nathanael S. Gray

BTK is a member of the TEC family of non-receptor tyrosine kinases whose deregulation has been implicated in a variety of B-cell-related diseases. We have used structure-based drug design in conjunction with kinome profiling and cellular assays to develop a potent, selective, and irreversible BTK kinase inhibitor, QL47, which covalently modifies Cys481. QL47 inhibits BTK kinase activity with an...

Journal: :American journal of cancer research 2016
Hsu-Ping Kuo Scott A Ezell Sidney Hsieh Karl J Schweighofer Leo Wk Cheung Shiquan Wu Mutiah Apatira Mint Sirisawad Karl Eckert Yu Liang Jeff Hsu Chun-Te Chen Darrin Beaupre Betty Y Chang

Diffuse large B cell lymphoma (DLBCL) is a heterogeneous lymphoma and the most common subtype of non-Hodgkin lymphoma, accounting for roughly 30% of newly diagnosed cases in the United States. DLBCL can be separated into the activated B cell-like (ABC) and germinal center B cell-like (GCB) subtypes, with distinct gene expression profiles, oncogenic aberrations, and clinical outcomes. ABC-DLBCL ...

Journal: :Journal of cell science 2005
Péter Várnai Tzvetanka Bondeva Péter Tamás Balázs Tóth László Buday László Hunyady Tamas Balla

Several pleckstrin-homology (PH) domains with the ability to bind phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3, PIP3] were expressed as green fluorescent protein (GFP) fusion proteins to determine their effects on various cellular responses known to be activated by PIP3. These proteins comprised the PH domains of Akt, ARNO, Btk or GRP1, and were found to show growth-factor-stimul...

2018
Erika Tissino Dania Benedetti Sarah E M Herman Elisa Ten Hacken Inhye E Ahn Kari G Chaffee Francesca Maria Rossi Michele Dal Bo Pietro Bulian Riccardo Bomben Elisabeth Bayer Andrea Härzschel Julia Christine Gutjahr Massimiliano Postorino Enrico Santinelli Ayed Ayed Francesco Zaja Annalisa Chiarenza Gabriele Pozzato Alexandre Chigaev Larry A Sklar Jan A Burger Alessandra Ferrajoli Tait D Shanafelt Adrian Wiestner Giovanni Del Poeta Tanja Nicole Hartmann Valter Gattei Antonella Zucchetto

The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib, which antagonizes B cell receptor (BCR) signals, demonstrates remarkable clinical activity in chronic lymphocytic leukemia (CLL). The lymphocytosis experienced by most patients under ibrutinib has previously been attributed to inhibition of BTK-dependent integrin and chemokine cues operating to retain the tumor cells in nodal compartments....

Journal: :International immunology 2001
T Kouro K Nagata S Takaki S Nisitani M Hirano M I Wahl O N Witte H Karasuyama K Takatsu

Formation of the pre-BCR complex is a critical check point during B cell development and induces the transition of pro-B to pre-B cells. CD79b (Igbeta) is a signaling component in the pre-BCR complex, since differentiation to the pre-B phenotype is induced by cross-linking the CD79b expressed on developmentally arrested pro-B cells from recombination-activating gene (RAG)-2-deficient mice. Brut...

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