1. Genovese MC, Becker JC, Schiff M et al. Abatacept for rheumatoid arthritis refractory to TNF alpha inhibition. N Eng J Med 2005;353:1114–23. 2. Voll RE, Kalden JR. Do we need new treatment that goes beyond TNF blockers for rheumatoid arthritis? Ann NY Acad Sci 2005;1051:799–810. 3. Kennedy T, McCabe C, Struthers G et al. BSR guidelines on standards of care for persons with rheumatoid arthrit...

The objectives of coring and downhole logging at this site are tied to completing the transect of scientific drill sites across the Northern Cascadia Margin to further constrain models for the formation of marine gas hydrate in a subduction zone acretionary prism. The depth to the BSR rapidly becomes shallower around this site and is only half the depth (~125 mbsf) than at Site U1327 (~225) mbs...

We study different solutions of the so-called blind source recovery (BSR) problem: Given an m-dimensional mixture random process x(t) and an m× n mixing matrix A, solve the underdetermined equation x(t) = As(t)+ e(t) with the unknown n-dimensional source process s(t) and noise e(t). For simplicity, we will assume that the processes are i.i.d. Moreover, s(t) has to satisfy additional assumptions...

We investigate the computational power of parallel models with directed reconfigurable buses and with shared memory. Based on feasibility considerations present in the literature, we split these models into “heavyweight” (directed reconfigurable buses, the Combining PRAM, and the BSR) and “lightweight,” (all the other PRAMs) and then find that the heavyweight class is strictly more powerful tha...

These guidelines have been developed for use by prescribing secondary-care rheumatologists. They are intended to indicate which adult patients with rheumatoid arthritis (RA) may benefit from the anti-tumour necrosis factor (anti-TNF) therapies, precautions that need to be taken in their use and to highlight potential side-effects from these therapies. The previous guidelines applied to the then...

s | 3 of adverse effects that currently limit the use of opioids in the clinic. Supported by USPHS Grant K05DA017918 PM288 Preclinical Evaluation of Neutral Cannabinoid CB1 Receptor Antagonists and Cannabinoid CB1 Receptor Negative Allosteric Modulators for Treating Drug Addiction Eliot L. Gardner1, Guo-Hua Bi1, Ganesh Thakur2, Alexandros Makriyannis2, Herbert H. Seltzman3, Xiang-Hu He4, Zheng-...

s | 3 of adverse effects that currently limit the use of opioids in the clinic. Supported by USPHS Grant K05DA017918 PM288 Preclinical Evaluation of Neutral Cannabinoid CB1 Receptor Antagonists and Cannabinoid CB1 Receptor Negative Allosteric Modulators for Treating Drug Addiction Eliot L. Gardner1, Guo-Hua Bi1, Ganesh Thakur2, Alexandros Makriyannis2, Herbert H. Seltzman3, Xiang-Hu He4, Zheng-...

The rewarding effect produced by electrical stimulation of some lateral hypothalamic sites is modulated by chronic food restriction and weight loss. The sensitivity of the rewarding effect to restriction predicts the modulation of brain stimulation reward (BSR) by the adiposity hormone, leptin. The present study examined the effect of corticotropin-releasing hormone (CRH) on the rewarding effec...

The article explores opportunities for the sustainable economic development of coastal territories in Baltic Sea region (BSR) arising blue economy sectors framework digital transformation. study argues that more active commercialisation territorial resources can facilitate BSR territories, following digitally-driven innovations. paper provides an overview methodological approaches to sustainabi...

Various spectral control techniques can be applied to improve the performance of a thermophotovoltaic (TPV) device. For example, back surface reflector (BSR) is common structure TPV devices. A conventional metal BSR enhances photogeneration rate by increasing absorption probability photons via reflections, affording second chance for absorption. However, effects passivation and external lumines...