Brugada Syndrome (BS) is a hereditary disorder characterized by primary electrical abnormality, absence of structural heart disease, an elevated risk sudden death, polymorphous ventricular tachycardia, and fibrillation, which mainly affects young men

We describe a case of an otherwise healthy 48-year-old man who survived aborted sudden cardiac death (SCD). His ECG showed ST segment elevation in inferior leads, therefore an acute coronary syndrome was suspected. However, serial troponin T and CPK-MB were negative, echocardiogram was unremarkable and exercise test was negative. On the basis of electrophysiological study, positive ajmaline tes...

Brugada syndrome is an autosomal dominantly inherited channelopathy estimated to be responsible for 4e12% of all sudden deaths, particularly among middle-aged men. It is characterized by ST-segment elevation in the right precordial leads, in the absence of acute coronary syndrome. This report discuses a patient with subarachonoid hemorrhage who developed the characteristic electrocardiographic ...

BRUGADA SYNDROME displays characteristic electrocardiographic (ECG) changes consisting of ST elevation in the anterior chest leads (V1-V3) and incomplete right bundlebranch block. It often presents with syncope or sudden death. As Brugada syndrome is being increasingly recognized, more patients with this syndrome will present for ICD implantation and other noncardiac surgery. The potential phar...

It has been observed that the incidence of heart failure and Brugada syndrome are higher in men, while women are more likely to have QT interval prolongation and develop torsades de pointes (TdP). Over the past decade, new studies have improved our understanding of the mechanisms of abnormal repolarization and the relationship between gender differences in cardiac repolarization and presentatio...

Brugada syndrome is characterized by right bundle branch block and ST-segment elevation in the right precordial ECG leads. Familial transmission is frequent and approximately 25% of cases exhibit mutations in the SCN5A gene. We analyzed the sequence of this gene in 25 Spanish patients with Brugada syndrome. In 4 (16%), we found mutations that had not previously been described: three were amino ...

[1] Remme AA, Wever EF, Wilde AA, Derksen R, Hauer RN. Diagnosis and long-term follow-up of the Brugada syndrome in patients with idiopathic ventricular fibrillation. Eur Heart J 2001; 22: 400–9. [2] Antzelevitch C. The Brugada syndrome: diagnostic criteria and cellular mechanisms. Eur Heart J 2001; 22: 353–6. [3] Nava A, Canciani B, Schiavinato ML, Martini B La repolarisation precoce dans le p...

First introduced as a new clinical entity in 1992, the Brugada syndrome is associated with a relatively high risk of sudden death in young adults, and occasionally in children and infants. Recent years have witnessed a striking proliferation of papers dealing with the clinical and basic aspects of the disease. Characterized by a coved-type ST-segment elevation in the right precordial leads of t...

BACKGROUND Brugada pattern on electrocardiogram (ECG) is seen when there are at least 2 mm J-point elevation and 1 mm ST-segment elevation in two or more of the right precordial leads, with right bundle-branch block (RBBB)-like morphology. Elevation of a coved-type shape in leads V1 and V2 is consistent with type I Brugada pattern, whereas elevation of a saddle-back configuration distinguishes ...

BACKGROUND In the present study, clarification of the prevalence of the Brugada-type electrocardiogram (ECG) and the incidence of spontaneous ventricular fibrillation (VF) that occurred with the Brugada-type ECG in patients with sick sinus syndrome (SSS) was determined. METHODS AND RESULTS A total of 487 consecutive patients (men 45%, mean age 69.9+/-12.3 years), who were defined as having an...