Although brown adipose tissue is important with regard to energy balance, the molecular mechanism of brown adipocyte differentiation has not been extensively studied. Specifically, regulation factors at the level of protein modification are largely unknown. In this study, we examine the changes in the expression level of enzymes which are involved in protein lysine methylation during brown adip...

Th e aim of the study was to compare carcass traits between Cika and Brown cattle of all slaughter categories. Th e data used were collected in Slovenian slaughterhouses from 2007 to 2010. Aft er the slaughter carcass weight was recorded and carcass conformation and fatness were scored according to the EUROP system. Net daily gain was calculated. Data were analysed by GLM procedure of statistic...

Sun-like stars have stellar, brown dwarf and planetary companions. To help constrain their formation and migration scenarios, we analyse the close companions (orbital period < 5 years) of nearby Sun-like stars. By using the same sample to extract the relative numbers of stellar, brown dwarf and planetary companions, we verify the existence of a very dry brown dwarf desert and describe it quanti...

The Red Dog Zn-Pb deposits are hosted in organic-rich mudstone and shale of the Mississippian Kuna Formation. A complex mineralization history is defined by four sphalerite types or stages: (1) early brown sphalerite, (2) yellow-brown sphalerite, (3) red-brown sphalerite, and (4) late tan sphalerite. Stages 2 and 3 constitute the main ore-forming event and are volumetrically the most important....

Adipose (fat) tissues contain white, brown, and beige adipocytes. White adipocytes store extra energy in the form of lipids; ectopic and excessive accumulation of white adipose in the body leads to overweight and obesity, which often causes insulin resistance and Type 2 diabetes. Brown adipocytes, in contrast, contain hundreds of mitochondria per cell, dissipate energy into heat, and are negati...

Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1alpha. We could then efficiently knockdown PGC-1beta expression by shRNA expression. Lo...

There is a correlation between obesity and the amount of brown adipose tissue; however, the molecular mechanism of brown adipogenic differentiation has not been as extensively studied. In this study, we performed a protein tyrosine phosphatase (PTP) profiling analysis during the brown adipogenic differentiation of mouse primary brown preadipocytes. Several PTPs, including PTPRF, PTPRZ, and DUSP...

Brown clustering is an established technique, used in hundreds of computational linguistics papers each year, to group word types that have similar distributional information. It is unsupervised and can be used to create powerful word representations for machine learning. Despite its improbable success relative to more complex methods, few have investigated whether Brown clustering has really b...

We review five mechanisms for forming brown dwarfs: (i) turbulent fragmentation of molecular clouds, producing very low-mass prestellar cores by shock compression; (ii) collapse and fragmentation of more massive prestellar cores; (iii) disc fragmentation; (iv) premature ejection of protostellar embryos from their natal cores; and (v) photo-erosion of pre-existing cores overrun by HII regions. T...

We show that the dearth of brown dwarfs in short-period orbits around Solar-mass stars – the brown dwarf desert – can be understood as a consequence of inward migration within an evolving protoplanetary disc. Brown dwarf secondaries forming at the same time as the primary star have masses which are comparable to the initial mass of the protoplanetary disc. Subsequent disc evolution leads to inw...