Background: Asthma is an allergic airway inflammatory disease in which B cell activation plays a pivotal role. CXCL13 is a family member of CXC chemokines involved in B cell differentiation and activation. The purpose of this research is to explore the correlation between serum CXCL13 levels and the severity of the disease. Methods: A total of 31 patients with acute bronchial asthma, 29 patient...

BACKGROUND Cysteinyl-leukotrienes are mediators of inflammatory responses in bronchial asthma. We studied the genes encoding the enzymes involved in their synthesis to identify risk factors for asthma. The promoter polymorphisms LTC4S -444 A/C, ALOX5 -176/-147, and ALOX5AP -169/-146 have been reported to be associated with bronchial asthma. METHODS We analyzed the effects of LTC4S -444 A/C, A...

Sir, A 45-year-old man was admitted with history of painful, sequential multiple peripheral nerve involvement for four months. On questioning he revealed history of allergic rhinitis with recurrent nasal polyps, bronchial asthma for two years, weight loss, joint pains with swelling and Raynaud’s phenomenon of four months duration. Examination revealed skin rash and features of mononeuritis mult...

We report a case of a 72-year-old woman with Churg-Strauss syndrome, who presented with intestinal perforation. She has had bronchial asthma with peripheral blood eosinophilia for 30 years. Gross findings of a resected colon showed multiple ulcers with perforation. Histologic findings demonstrated transmural inflammation infiltrated with large numbers of eosionophils, neutrophils and lymphoplas...

451 TheRelationship BetweenEmotional Cognition and the Symptom Gap inPatientswithBronchialAsthma: theEffects ofAlexithymia and Empathy Sonomi Nakajima. Clinical Psychology, Graduate School of Human Sciences, Osaka University, Suitashi, Japan. Background: When symptoms are poorly controlled, patients with bronchial asthma may show a symptom gap: a cognitive divergence between the true severity o...

451 TheRelationship BetweenEmotional Cognition and the Symptom Gap inPatientswithBronchialAsthma: theEffects ofAlexithymia and Empathy Sonomi Nakajima. Clinical Psychology, Graduate School of Human Sciences, Osaka University, Suitashi, Japan. Background: When symptoms are poorly controlled, patients with bronchial asthma may show a symptom gap: a cognitive divergence between the true severity o...

The pathogenetic mechanism of nonatopic asthma has not yet been defined. The idea of a possible involvement of autoimmunity in the pathogenesis of nonatopic asthma has been proposed by earlier studies. To evaluate the possible involvement of autoimmune response against bronchial epithelial cell in the pathogenesis of nonatopic asthma, we measured circulating autoantibodies to cultured human bro...

451 TheRelationship BetweenEmotional Cognition and the Symptom Gap inPatientswithBronchialAsthma: theEffects ofAlexithymia and Empathy Sonomi Nakajima. Clinical Psychology, Graduate School of Human Sciences, Osaka University, Suitashi, Japan. Background: When symptoms are poorly controlled, patients with bronchial asthma may show a symptom gap: a cognitive divergence between the true severity o...

BACKGROUND The significant value of tests used to certify the diagnosis of occupational asthma due to persulphate salts remains uncertain. AIMS To validate the specific inhalation challenge (SIC) test for the diagnosis of occupational asthma. METHODS Eight patients with occupational asthma due to persulphate salts, eight patients with bronchial asthma who were never exposed to persulphate s...

In the first half of the last century tuberculosis was the main focus of attention amongst all respiratory diseases. Bronchial asthma is a serious global health problem. The present study was carried out to estimate magnesium levels in serum in pulmonary tuberculosis and bronchial asthma cases and to compare them with the serum magnesium levels of controls. This study was undertaken in 120 subj...