Histological changes in breast tissue after radiotherapy were evaluated. Changes in tissue from 17 patients previously treated for breast cancer by surgery and radiotherapy were compared with those seen in a control group treated with surgery alone. Vascular and epithelial changes were seen only in tissue from patients who had received radiotherapy and, therefore, seemed to be relatively specif...

Secondary angiosarcoma is an aggressive tumor that can develop in breast cancer patients treated with conserving therapy and radiotherapy. The symptoms can be misleading, whereas mammography and fine-needle aspiration (FNA) are typically negative in early stage of the disease. A high grade of clinical suspicion is very important for early diagnosis. A case of angiosarcoma involving breast paren...

AIMS New technology - specifically intensity-modulated radiotherapy (IMRT) - is now being applied to breast radiotherapy and a recent dosimetric analysis confirmed the advantages of IMRT over 'wedge-only' plans. Such application to everyday practice raises new issues and here we present the early experience of IMRT-based breast irradiation in a single centre. MATERIALS AND METHODS We present ...

Our study is considered a continuing effort in radiation therapy treatment of breast cancer. It is concerned a comparison study between the effect of hyperfractionation radiotherapy (a short term course) and hypofractionation radiotherapy (a long term course) of treatment photon doses on breast cancer cells. The comparison is done with refereeing to normal breast tissue measurements using flow ...

BACKGROUND The selection of therapies for breast cancer is today based on prognostic features (chemotherapy, radiotherapy), hormone receptor status (hormonal therapy) and HER-2 status (trastuzumab therapy). HER-2, p53 and BCL-2 are tumour-related proteins that have the potential to further improve individualisation of patient management, by predicting response to chemotherapy, hormonal therapy ...

PURPOSE/OBJECTIVES To describe fatigue in women with breast cancer undergoing radiotherapy and to explore the impact of fatigue on their health status. DESIGN Prospective, descriptive, repeated measures. SETTING A major oncology center, Saint Savvas Cancer Hospital, in Athens, Greece. SAMPLE Consecutive sample of 106 women (mean age = 55 + 12), with histologically confirmed diagnosis for ...

PURPOSE The fragile-site associated tumor suppressor (FATS) is a newly identified tumor suppressor involved in radiation-induced tumorigenesis. The purpose of this study was to characterize FATS expression in breast cancers about radiotherapy benefit, patient characteristics, and prognosis. RESULTS The expression of FATS mRNA was silent or downregulated in 95.2% of breast cancer samples compa...

Breast cancer (BC) is a heterogeneous disease, and different tumor characteristics and genetic variation may affect the clinical outcome. The FANCM c.5101C > T nonsense mutation in the Finnish population associates with increased risk of breast cancer, especially for triple-negative breast cancer patients. To investigate the association of the mutation with disease prognosis, we studied tumor p...

Introduction: Breast cancer is the most common cancer among women. Radiotherapy plays an important role in the treatment of breast cancer and essential part of the standard treatment after breast-conserving surgery, routinely done to eliminate the microscopic residual cancer. The heart and lungs are one of the most important organs at risk of breast cancer radiotherapy that th...

OBJECTIVE To identify any excess mortality caused by adjuvant radiotherapy for early breast cancer. DESIGN Prospective randomised clinical trial. Two thousand subjects needed for study to have a 90% chance of detecting a difference in survival rate of 7% with 95% significance. Patients were followed up until June 1988, giving follow up of 158-216 months. SETTING A multicentre trial mainly d...