High breast density (HBD) tends to be seen as a significant and independent risk factor for breast cancer. This article describes a methodological and quantitative study of the variables selected by the large DMIST study, i.e., age, hormonal status and breast density, in correlation with cancer occurrence frequency. The statistical analysis of cancer rates in every patient subgroup of a study i...

BACKGROUND Mammographic density is a potentially modifiable risk factor for breast cancer. To what extent mammographic density is a predictor for both hormone receptor-positive and hormone receptor-negative tumors is unclear. Even less is known about whether mammographic density predicts subtypes of breast cancer defined by expression status of the three receptors: estrogen receptor (ER), proge...

BACKGROUND Mammographic density is an established risk factor for breast cancer and has a strong heritable component. Genome-wide association studies (GWAS) for mammographic density conducted in women of European descent have identified several genetic associations, but none of the studies have been tested in Asians. We sought to investigate whether these genetic loci, and loci associated with ...

BACKGROUND Mammographic breast density and endogenous sex-hormone levels are both strong risk factors for breast cancer. This study investigated whether there is evidence for a shared genetic basis between these risk factors. METHODS Using data on 1,286 women from 617 families, we estimated the heritabilities of serum estradiol, testosterone, and sex-hormone binding globulin (SHBG) levels and...

[Purpose] The purpose of this study was to analyze the relationship between breast density and bone mineral density after menopause. [Subjects and Methods] The subjects were 130 patients who participated in a bone densitometry test and had a mammogram taken between January 1st, 2013 to October 1st, 2014. The mammograms were scored breast imaging-reporting and data system. Grade 1 indicates almo...

Mammographic density has been proven as an independent risk factor for breast cancer [1, 2]. Recently, a large, population-based longitudinal study has confirmed that breast density was also associated with risk of developing ductal carcinoma in situ (DCIS) [3]. The literature report, or the biological basis for cancer development, did not indicate that there is a difference in the association ...

Background Some studies have already proposed an inverse association between vitamin D levels and breast density. As breast density is already considered an established risk factor for breast cancer, such a connection could offer a new starting point for the prevention of breast cancer. Material and Methods To investigate this suggested connection, a total of 412 pre- and 572 post-menopausal wo...

[Purpose] The aim of this study was to identify biochemical markers related to breast density. The study was performed with 200 patients who received mammography and biochemical marker testing between March 1, 2014 to October 1, 2014. [Subjects and Methods] Following the American College of Radiology, Breast Imaging Reporting and Data System (ACR BI-RADS), breast parenchymal pattern density fro...