In the past decade the molecular basis of many inherited syndromes has been unravelled. This article reviews the clinical and genetic aspects of inherited syndromes that are characterised by skin appendage neoplasms, including Cowden syndrome, Birt-Hogg-Dube syndrome, naevoid basal cell carcinoma syndrome, generalised basaloid follicular hamartoma syndrome, Bazex syndrome, Brooke-Spiegler syndr...

Familial cylindromatosis (FC) is an autosomal dominant disorder with apparently complete penetrance, but variable expression. There is an increasing evidence that FC is clinically, genetically, and histologically heterogeneous disorder as the simultaneous occurrence of cylindromas and other tumors of skin appendages within the affected individuals and families. The presence of multiple scalp cy...

B rooke-Spiegler syndrome (BSS) includes the combination of spiradenomas, cylindromas, and trichoepitheliomas. It has been postulated that BSS results from defects in the regulation of putative stem cells of the folliculosebaceous-apocrine unit. This follicular dysregulation may give rise to 3 different genodermatoses: familial cylindromatosis (FC), multiple familial trichoepithelioma (MFT), or...

BACKGROUND Appendageal skin tumors belong to a heterogenous group of tumors with specific histopathology. The aim of this study is to determine the pattern of appendageal tumors in skin biopsies done in our department. METHODS This is a 3-year retrospective descriptive study of all patients who were diagnosed to have skin appendageal tumors in our department, and the diagnoses were confirmed ...

background : breast cancer is one of the most frequent malignancies among iranian women. triple-negative breast cancer (tnbc) is referred to a type of breast cancer which three biomarkers of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (her2), are negative. materials and methods: in this case control study, immunohistopathologic data of patients with tn...

background: women's role in family and their participation in social, economical and cultural activities make them a part of development process. paying attention to women's health is a social investment. nowadays 70% of women suffer from breast pain and two third of these pains are periodical. among the pain killing methods, herbal medicine is more compatible with human body and has fewer side...

background: inflammatory breast cancer (ibc), a subgroup of locally advanced breast cancer (labc), is diagnosed based on clinical findings, and seems to be different from other types of labc. the purpose of this study was to compare clinicopathological characteristics and outcomes between inflammatory and non-inflammatory labc patients at breast cancer research center (bcrc), tehran, iran. meth...

background: breast cancer is third order malignancy in women among other malignancies.   various studies showed that incidence of breast cancer can be lower down by early detection of breast cancer. mammographic screening is considered more effective modality in detecting early stage breast cancer in women who are at elevated risk for breast cancer. the aim of this study is to report the result...

KIT (CD117, c-kit) is a receptor tyrosine kinase involved in the tumorigenesis of several neoplasms. KIT is expressed by the secretory cells of normal sweat glands. We studied the KIT expression and KIT mutational status in various benign and malignant tumors of eccrine and apocrine glands. We included a total of 108 cases comprising 10 benign and 6 malignant sweat gland tumors, and KIT express...

Adenoid cystic carcinoma, or cylindroma, usually presents in the salivary glands or in the upper respiratory passages. We report an unusual case of adenoid cystic carcinoma in a 45-year-old woman who presented with a three-year history of progressive right trigeminal sensory palsy, most pronounced in the second division. There was, in addition, a right trigeminal motor palsy and a partial right...