AIM The aim of this study was to evaluate factors affecting the risk for reexcision following breast-conserving surgery. Positive tumor margins are critical for local disease control following surgery for breast cancer. Several factors, including tumor size, multifocality, and an extensive in situ component, may be associated with a higher rate of repeat operations due to positive margins. This...

BACKGROUND In primary breast cancer, breast conserving surgery and mastectomy are equal options with regard to patient survival. We therefore investigated whether and how the type of surgery has impact on the patients' quality of life (QoL) in order to support individualized surgical concepts in treatment of breast cancer. 3 types of surgery are compared: breast-conserving surgery; modified rad...

Background: There is little literature comparing intraoperative ultrasound (IOUS) with radio-guided occult lesions localization (ROLL) in nonpalpable invasive tumors breast conserving surgery (BCS). a need to compare these two methods terms of safety and efficacy.

BACKGROUND AND AIMS The aim of this study was to analyze feasibility of day surgery in breast cancer patients with breast conserving surgery and sentinel node biopsy. MATERIAL AND METHODS The study was a randomized controlled trial comparing day surgery with one night hospital stay in breast cancer patients with breast conserving surgery and sentinel node biopsy. A total of 40 patients with ⩽...

background: breast conservation therapy (bct) is the standard of care for early stage breast cancer. the procedure can be a challenge for the surgeon if the lesion is non-palpable. for excision of non-palpable breast lesions, they should be localized precisely before surgery. there are different techniques such as the wgl (wire guided localization), roll (radio-guided occult lesion localization...

乳房温存オンコプラスティックサージャリー（OPBCS）ワーキンググループは，OPBCSの手技習得のためステップアップガイドを作成している．

The response rates to neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer (LABC) may vary and the risks may outweigh the benefits in poorly selected patients. This study investigated whether survivin expression, high-level Ki-67 expression, estrogen-receptor (ER) tumor status and high tumor grade are able to predict response to docetaxel-based NAC in LABC patients, in...

We evaluated the relationship between breast cancer survival and deprivation using data from the Irish National Cancer Registry. Cause-specific survival was compared between five area-based socioeconomic deprivation strata using Cox regression. Patient and tumour characteristics and treatment were compared using modified Poisson regression with robust variance estimation. Based on 21356 patient...

n engl j med 360;1 nejm.org january 1, 2009 63 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented...