OBJECTIVES/HYPOTHESIS Surgery and postoperative radiation therapy are commonly used in the treatment of advanced sinonasal cancer. However, post-treatment radiation changes to the brain often mimic radiologic findings suggestive of tumor recurrence, leading to potential unnecessary intracranial biopsies. The objective of this study was to determine clinical factors that predict signs of tumor r...

Abstract Spatiotemporal heterogeneity is a major factor contributing to the devastating prognosis of isocitrate-dehydrogenase (IDH)-wildtype glioblastoma. Genome-wide DNA methylation profiling allows stratification into several subgroups IDH-wildtype glioblastoma, which were shown have spatial in newly diagnosed tumors. However, temporal and its clinical relevance remains inconclusive. Tumor ti...

Background and Importance: The coexistence of pituitary adenoma and another type of brain tumor is a very rare clinical scenario. Even though such a presentation can be an incidental event but the possible pathogenesis of coexistence of different lesions in the sella and suprasellar region has not yet been elucidated. Case Presentation: Two cases of concomitant sellar and suprasellar region ...

background: preoperative determination of the extent of viable residual tumor is an important issue after neoadjuvant treatment. on the other hand, retrospective data suggest that breast-conserving surgery is feasible up to stage iiia breast cancer without preoperative therapy. methods: we retrospectively analyzed 164 patients who underwent breastconserving surgery followed by adjuvant chemothe...

Brain metastases originating from pancreatic cancer are associated with a dismal prognosis and, generally, therapeutic options remain palliative. We present the cases of two patients that developed brain metastases after resection of a pancreatic ductal adenocarcinoma. Brain metastases were resected successfully and neither patients developed any further tumor recurrence. These cases demonstrat...

Abstract Glioblastoma (GBM) is a devastating brain cancer with median overall survival of mere 12-15 months. Patients receive the standard care treatment, comprised maximum surgical resection, ionizing radiation, and temozolomide chemotherapy, however tumor inevitably recurs. Recurrent GBM more invasive, difficult to resect, treatment resistant. stem cells (BTSCs), sub-population stem-like abil...

Abstract Antibody-based conjugates (ADCs) have transformed the treatment of Her2+ breast and other cancers. Unfortunately, CNS remains a sanctuary site for many such patients in part due to differential activity macromolecules across blood-brain tumor barriers. Trastuzumab deruxtecan (T-DXd), high-payload ADC, was recently found improve progression-free survival cancer compared with prior-gener...

INTRODUCTION (11)C-methonine ([(11)C]-MET) positron emission tomography-computed tomography (PET-CT) is a well-established technique for evaluation of tumor for diagnosis and treatment planning in neurooncology. [(11)C]-MET reflects amino acid transport and has been shown to be more sensitive than magnetic resonance imaging (MRI) in stereotactic biopsy planning. This study compared fluorodeoxyg...

Glioblastoma, the most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. Bevacizumab, a monoclonal antibody against the vascular endothelial growth factor receptor, has increasingly been used in the treatment of recurrent glioblastoma. It has achieved excellent rates of radiographic response, but most patients will progress after only a f...