Estrogen receptors (ERα and ERβ) in the brain play critical roles in maintaining brain tissue homeostasis and in tissue repair after injury. Growth of cancer metastasis in the brain is a constant damaging process. The role of ERs of the host in the progression of cancer brain metastasis is unknown. To determine the role of ERβ of host in the progression of lung cancer brain metastasis, we used ...

AIM To investigate the clinical features, prognostic factors and survival times of cervical cancer patients with brain metastasis. MATERIAL AND METHODS We retrospectively reviewed the medical records of 820 patients with cervical cancer. Data were analyzed using SPSS version 12.0 statistical software (SPSS, Chicago, IL, USA). Overall survival, time interval from diagnosis of cervical cancer t...

Brain metastasis occurs with a fairly high frequency, in 25–35% of cancer patients [1]. Be‐ cause brain metastasis directly affects prognosis, quality of life (QOL), and performance status (PS), treatment is crucial. Survival time is reported to be 1 month in the case of untreated brain metastasis [2], 2 months with steroid treatment alone [3], and 3-6 months with whole-brain radiotherapy (WBRT...

Primary lung cancer with gastric metastasis is rare to see in the world, little known about its characteristics. Here, we describe first case of primary adenocarcinoma and skin metastases along a review literature help clinical decision making. A 49-year-old woman admitted our department for abdominal distension. The immunohistochemistry staining biopsy fundus, back showed positive CK5/6, TTF-1...

Whole brain radiotherapy (WBRT) is a mainstay of treatment in patients with both identifiable brain metastases and prophylaxis for microscopic disease. The use of WBRT has decreased somewhat in recent years due to both advances in radiation technology, allowing for a more localized delivery of radiation, and growing concerns regarding the late toxicity profile associated with WBRT. This has pro...

PURPOSE Brain metastases affect 25% of patients with non-small cell lung cancer (NSCLC). We hypothesized that the expression of genes in primary NSCLC tumors could predict brain metastasis and be used for identification of high-risk patients, who may benefit from prophylactic therapy. EXPERIMENTAL DESIGN The expression of 12 genes was measured by real-time quantitative reverse transcriptase P...

BACKGROUND AND PURPOSE Brain metastasis is a relatively uncommon event in the natural history of soft tissue sarcomas. The increasing use of chemotherapy may have caused a reduction in local relapses as well as distant failures leading to an improvement in survival, thereby allowing metachronous seeding of the brain, a sanctuary site. The purpose of this report is to increase awareness amongst ...