Pervious studies have shown that pentoxifylline (PTX) has beneficial effects in reduction of stroke and brain trauma injuries in experimental animals. However, there is very little and controversial information about the effect of PTX on brain edema in cerebral ischemia. Therefore, the aim of this study was to determine the effects of different doses of PTX on brain edema and neurological m...

background: nepeta dschuparensis bornm (np) is used as a medicinal herb in iran. in traditional medicine, this herb is extensively employed for curing ailments such as cardiovascular diseases. np has antioxidant and anti-inflammatory properties. this project examined the effects of the np extract on cyclooxygenase-2 (cox-2) and interleukin-1β (il-1β) protein levels and its efficacy in neuroprot...

Objective(s) The brief interruption of cerebral blood flow causes permanent brain damage and behavioral dysfunction. The hippocampus is highly vulnerable to ischemic insults, particularly the CA1 pyramidal cell layer. There is no effective pharmacological strategy for improving brain tissue damage induced by cerebral ischemia. Previous studies reported that pentoxifylline (PTX) has a neuroprot...

Differential screening of gerbil brain hippocampal cDNA libraries was used to search for genes expressed in ischemic, but not normal, brain. The methylmalonyl-CoA mutase (MCM) cDNA was highly expressed after ischemia and showed a 95% similarity to mouse and 91% similarity to the human MCM cDNAs. Transient global ischemia induced a fourfold increase in MCM mRNA on Northern blots from both hippoc...

Background The pathophysiology of neurodegenerative diseases, particularly Alzheimer’s disease is multifactorial. However, with scientific evidences suggesting that various antioxidants possess different protective mechanisms, thus hypothetically/theoretically no single natural compound can adequately abrogate these plethora cascades. Hence, there a need for paradigm shift from the usual monoth...

BACKGROUND/AIM Brain ischemia and treatment are important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most significant causes of damage. Currently there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in syringic acid, previous...

background: stroke is the third leading cause of death. hypothermia has been recognized as an effective method in reducing brain injury. in this study, we assessed the effects of granulocyte colony-stimulating factor (g-csf) as a neuroprotective agent and mild hypothermia on mortality, behavioral function, infarct volume, and brain edema in wistar rats. methods: forty male rats were used in fiv...

Objective(s): Morphine dependence (MD) potently protects heart against ischemia reperfusion (IR) injury through specific signaling mechanisms, which are different from the pathways involved in acute morphine treatment or classical preconditioning. Since opioid receptor density changes post cerebral ischemia strongly correlated with brain histological damage, in the present study, we tried to el...