The ovary contains a pool of primordial follicles containing oocytes arrested in meiosis that are the source of developing follicles for the female. Growth and differentiation factor-9 (GDF-9) is a member of the transforming growth factor beta superfamily of growth factors, and follicles of GDF-9 knockout mice arrest in the primary stage of development. The effect of GDF-9 treatment on the prim...

The ultimate aim of ovarian cryopreservation research is naturally to increase the effectiveness of this fertility preservation procedure in female cancer victims and much of this research on whole ovary cryopreservation, ovarian cortex cryopreservation and transplantation has been performed in animal models. However, ovarian cryopreservation could also be used in the future in programs with th...

ObjectiveTo report the utility of combined transvaginal and transabdominal oocyte retrieval in a patient with an ectopic ovary unicornuate uterus.DesignVideo case demonstration technique.Setting(s)University-affiliated fertility center.Patient(s)A 35-year-old woman, gravida 0, 6-month history infertility who presented to our center for evaluation. Hysterosalpingography revealed left uterus pate...

The relaxin-like factor (RLF) is a novel member of the insulin-IGF-relaxin family of hormones and growth factors. Also known as the Leydig cell insulin-like factor (Ley-I-L), this peptide and the mRNA encoding it appear to be expressed in very large quantities in the Leydig cells of the testis. However, it is also produced in the ovary of a number of species in both follicular theca cells and i...

The Plackett-Burman design and support vector machine (SVM) were reported to be used on many fields such as some feature selections, protein structure prediction, or forecasting of other situations. Here, with suspension adapted Chinese hamster ovary (CHO) cells as the object of study, a serum-free medium for the culture of CHO cells in suspension was optimized by this method. Support vector ma...

Three lignan derivatives, (-)-taxiresinol (1), (-)-3'-demethylisolariciresinol-9'-hydroxyisopropylether (2) and (-)-3-demethylisolariciresinol (3), previously isolated from the heart-wood of Taxus baccata L. (Taxaceae) were investigated for cytotoxicity against the Oncology Cell Line Panel (breast, colon, ovary, prostate, lung and a normal adult bovine aortic endothelial cell line) as well as f...