نتایج جستجو برای: boron neutron capture therapy bnct

تعداد نتایج: 829713  

Journal: :iranian biomedical journal 0
داریوش شهبازی گهرویی daryoush shahbazi-gahrouei barry j. allen mark williams mark williams barry j. allen

two new potential magnetic resonance imaging contrast agents, gd-hematoporphyrin (gd-h) and gd-tetra-carboranylmethoxyphenyl-porphyrin (gd tcp), were synthesized and applied to nude mice with human melanoma (mm 138) xenografts. these agents showed a high relaxivity because of their greater potential to coordinate water molecules. the reduction of t1 relaxation times of 16 and 21% was observed i...

2013
Kakuji Okumura Yuko Kinashi Yoshihisa Kubota Erika Kitajima Ryuichi Okayasu Koji Ono Sentaro Takahashi

Understanding the biological effects of neutron mixed-beam irradiation used for boron neutron capture therapy (BNCT) is important in order to improve the efficacy of the therapy and to reduce side effects. In the present study, cell viability and DNA double-strand breaks (DNA-DSBs) were examined in Chinese hamster ovary cells (CHO-K1) and their radiosensitive mutant cells (xrs5, Ku80-deficient)...

Introduction: Boron neutron capture therapy (BNCT) is a method of cancer treatment and potentially, two borono-L-phenylalanine (BPA) and sodium borocaptate (BSH) are used in BNCT as common boron carriers. Some previous studies have shown that the dose rate is directly related to boron concentration in the tissue. This study aimed to simulate the structure of boron carriers and brain tumor compo...

Alireza Sadremomtaz, Peyvand Taherparvar Sepideh Gholami

Introduction: Neutrons have many applications in various fields, such as medicine. The important application of neutron in medical science is in Boron Neutron Capture Therapy (BNCT). Because of this, determination of neutron dose and flux is critical for the health maintaining of workers and patients exposed to this beam. The neutron radioisotope sources produce gamma rays in ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2001
C R Gibson A E Staubus R F Barth W Yang N M Kleinholz R B Jones K Green-Church W Tjarks A H Soloway

Boron neutron capture therapy (BNCT) is based on a nuclear capture reaction that occurs when boron-10, a stable isotope, is irradiated with low energy neutrons to produce high-energy alpha particles and recoiling lithium-7 nuclei. The purpose of the present study was to determine what urinary metabolites, if any, could be detected in patients with brain tumors who were given sodium borocaptate ...

2012
Li Deng Chaobin Chen Tao Ye Gang Li

BNCT incorporates the targeting principles of chemotherapy and the anatomical localization principles of conventional radiotherapy but with three distinct advantages:  Current boron compounds at the required concentrations are non-toxic.  The time interval between drug administration and neutron irradiation can be chosen to maximize the concentration differential between tumour and normal tis...

2005
Gerard Bunick Leif Hanson Paul Langan Xinmin Li Benno P. Schoenborn Catherine L. Lawson Alexander S. Chin Chick C. Wilson Nobuo Niimura Ichiro Tanaka Toshiyuki Chatake Kazuo Kurihara Mitsuru Maeda Shigeki Arai Irina Tsyba Robert Bau Michael W. W. Adams Francis E. Jenney

Journal: :IEEE Transactions on Nuclear Science 2023

A lithium fluoride (LiF)-silicon (Si)-based neutron detector was developed for real-time measurement of beams boron capture therapy (BNCT). Detection efficiencies thermal neutrons were measured at the national standard field in Japan and simulated using a Monte Carlo simulation code to evaluate absolute BNCT fluence rates. The detection agreed excellently with experimental results, within an er...

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