Bone cancer pain is the most severe among cancer pain and is often resistant to current analgesics. Thus, the development of novel analgesics effective at treating bone cancer pain are desired. Platelet-activating factor (PAF) receptor antagonists were recently demonstrated to have effective pain relieving effects on neuropathic pain in several animal models. The present study examined the pain...

introduction: the aim of the present study was to evaluate the efficacy and safety profile of bone palliative therapy following administration of 153sm-edtmp in patients with intractable metastatic bone pain. methods: sixteen patients (9 male, 7 female) aged 29-80 years (57.3±16.7 years) with severe metastasis-related bone pain resistant to analgesic medications were enrolled in the study. all...

introduction: the selective medication for pain control in many clinical situations is morphine but its complications prevent its widespread use. ketamine has been introduced as an alternative for morphine in some studies. however, the efficacy of its solitary use has not yet been evaluated. therefore, the present study was undertaken to evaluate the effect of ketamine alone in relieving pain i...

IMAGE-guided percutaneous methods of tumor destruction have proven effective for treatment of benign bone tumors as well as for palliation of metastases involving bone and soft tissue sites beyond the liver and lung. Treatment of primary bone tumors is largely restricted to benign tumors, most notably osteoid osteomas, as a single-modality treatment or as an adjunct to surgical resection (1– 4)...

Bone metastases are the most common source of pain for patients with cancer. For pain that is refractory to conventional measures, microwave ablation (MWA) is an emerging alternative therapy. Studies show that MWA is effective in reducing pain and analgesic requirements while improving function. This article describes studies of MWA that include patients with bone metastases to a variety of loc...

Skeletal involvement in metastatic castrate-resistant prostate cancer (mCRPC) is common and results in significant morbidity and mortality. The interaction of prostate cancer with the bone microenvironment contributes to progression of cancer in the bone leading to skeletal-related events (SREs). Studies aimed at targeting the bone have been carried out over the recent years. Bisphosphonates ar...

PURPOSE/OBJECTIVES To examine pain severity, satisfaction with pain management, and patient-related barriers to pain management among patients with cancer in oncology units at a teaching hospital in Israel. DESIGN Descriptive, cross-sectional, correlational design. SETTING Oncology, hematology, and bone marrow trans-plantation (BMT) departments; oncology, hematology, and BMT daycare units; ...