Kleppe and colleagues use detailed cytokine profiling analyses to investigate the role of aberrant proinflammatory cytokine secretion in the pathogenesis of myeloproliferative neoplasms. Their analyses implicate constitutive activation of STAT3 in both malignant and nonmalignant bone marrow cell populations as a driver of aberrant cytokine secretion and as a cellular target mediating the therap...

Chondromyxoid fibromas account for <1% of primary bone neoplasms. We report one such case occurring in the distal fibula of a 27-year-old woman. The patient underwent curettage, followed by phenolisation, insertion of a Steinmann pin, and cementation. This treatment reduced morbidity, restored stability, and enabled rapid functional recovery. There was no recurrence after 2 years.

A rare case of Brodie's abscess of distal left tibia is presented in a child which was initially missed on clinical grounds alone. Differentiation from different bone neoplasms was done on radiological grounds. The patient was managed surgically with high dose intravenous antibiotics. Brodie's abscess is very rarely encountered in our reporting of X-rays.

56 malignant bone neoplasms (15 primary and 41 metastatic), diagnosed by fine-needle aspiration biopsy, are reported. 100% diagnostic accuracy was achieved. The results indicate that fine-needle aspiration biopsy can be a substitute for open surgical biopsy in selected cases.

conclusions based on evidence, dentists and dental health care professionals should consider periodontal disease as a risk factor for the development of neoplasms in the oral cavity. it also seems a good idea to provide periodontal therapy for patients with cancer to achieve ideal therapeutic results. results cancer of the oral cavity and periodontal disease are related from different aspects. ...

Perivascular epithelioid cell neoplasms represent a group of uncommon mesenchymal tumours with as yet undiscovered benign counterpart. Although perivascular have been described arising in most organ systems well soft tissue and bone, only small number reported the bladder. To date, there is no agreed system for predicting behaviour these tumours. We describe case neoplasm bladder 57-year-old ma...

Introduction. Myelodysplastic/myeloproliferative neoplasms represent a group of rare hematologic malignancies with concomitant characteristics two different disorders. There are cytopenias and cytoses dysplastic morphology in the circulating blood hyperplastic bone marrow, respectively. Many cytogenetic molecular features have been found this entity, but t(2;11)(p21;q23)del(5) (q22;q33) has not...

Parenteral nutrition-associated metabolic bone disease in children is manifested primarily as osteopenia and, on occasion, fractures. The etiology is likely multifactorial, with calcium and phosphate deficiency playing a major role in the preterm infant and with the role of aluminum toxicity yet to be clearly defined in this population. Lack of normal values of bone histomorphometry in the prem...

Angiosarcomas are rare aggressive neoplasms of vascular endothelial origin with a high metastatic rate and poor prognosis. Involvement of the bone marrow by the angiosarcoma is exceedingly uncommon, and there have only been a few cases reported in the literature to date. Clinical manifestations and common laboratory findings of bone marrow involvement can mimic other more common bone marrow-rep...