BACKGROUND The aim of this experimental study was to investigate the effects of strontium ranelate on bone regeneration in the mid-palatal suture in response to rapid maxillary expansion (RME). METHODS Thirty-six male 6-week-old Wistar rats were randomly divided into three groups, ie, an expansion only (EO) group, an expansion plus strontium ranelate (SE) group, and a control group. An orthod...

BACKGROUND The aim of this study was to use three-dimensional datasets to identify associations between treatment for adult crowding using Invisalign and interproximal enamel reduction (IER) and changes in the bone volume. METHODS A total of 60 digital cone beam computed tomography (CBCT) scans from 30 patients (28 women, two men; 30 CBCTs pretreatment, 30 posttreatment) were examined retrosp...

The aim of this review was to evaluate the current evidence regarding post-treatment effects tooth-bone-borne vs. bone-borne expanders. A search conducted in MEDLINE via PubMed, Web Science, Scopus, Cochrane Library, Google Scholar, and Open Gray; addition a hand reference lists selected articles creating alert electronic databases. Selection criteria included randomized prospective clinical tr...

PURPOSE Extensive tunnel expansion in hamstring anterior cruciate ligament (ACL) reconstruction can complicate revision surgery. The purpose of this study was to examine our hypothesis that compaction of a bone dowel into the tibial tunnel reduces the cross-sectional area of the tunnel on the day of surgery and limits tunnel expansion to that of the cross-sectional area of the reamer at 4 month...

Recent studies have indicated that the hematopoietic stem/progenitor cell (HSPC) niche, consisting of two major crucial components, namely osteoblasts (OBs) and mesenchymal stromal cells (MSCs), is responsible for the fate of HSPCs. Thus, closely mimicking the HSPC niche ex vivo may be an efficient strategy with which to develop new culture strategies to specifically regulate the balance betwee...

OBJECTIVE(S) Ex vivo expansion of hematopoitic stem cells is an alternative way to increase umbilical cord blood (UCB)-CD34+ cells for bone marrow transplantation. For this purpose demineralized bone matrix (DBM) and mineralized bone allograft (MBA) as two scaffolds based on bone matrix and stem cell niche, were simultaneously used to enhance the effect of human mesenchymal progenitor cells (MP...

Xanthoma of bone is a rare disorder which occurs due to cholesterol deposits in the bone. Clinically patients usually present with pain or fracture affected Radiologically it presents as lytic lesion, often cortical expansion disruption. associated hyperlipidemia but cases non- xanthoma are also reported, termed primary xanthoma. Here we case 46-year-old male who presented and swelling right mi...

Age-dependent changes in skeletal growth are important for regulating skeletal expansion and determining peak bone mass. However, how G protein-coupled receptors (GPCRs) regulate these changes is poorly understood. Previously, we described a mouse model expressing Rs1, an engineered receptor with high basal G(s) activity. Rs1 expression in osteoblasts induced a dramatic age-dependent increase i...

Mesenchymal stromal cells are present in very low numbers in the bone marrow, necessitating their selective expansion on tissue culture plastic prior to their use in tissue-engineering applications. MSC expansion is laborious, time consuming, unphysiological and not economical, thus calling for automated bioreactor-based strategies. We and others have shown that osteogenic grafts can be culture...

In this work, we investigated whether osteo-inductive constructs can be generated by isolationand expansion of sheep bone marrow stromal cells(BMSC) directly within three-dimensional (3D) ceramicscaffolds, bypassing the typical phase of monolayer (2D)expansion prior to scaffold loading. Nucleated cells fromsheep bonemarrowaspiratewere seeded into 3D ceramicscaffolds ...