The murine B-cell lymphoma 38C13 model was used to study the radiobiological effect of 13ll-monoclonal antibody (MAB) therapy com pared with dose equivalent external beam irradiation. Continuous expo nentially decreasing low dose rate (LDR) -y-irradiation, and multiply fractionated (MF) \-irradiation were compared with dose equivalent I31IMAH. The relative therapeutic efficacy of radioimmunothe...

The murine B-cell lymphoma 38C13 model was used to study the radiobiological effect of 131I-monoclonal antibody (MAB) therapy compared with dose equivalent external beam irradiation. Continuous exponentially decreasing low dose rate (LDR) gamma-irradiation, and multiply fractionated (MF) X-irradiation were compared with dose equivalent 131I-MAB. The relative therapeutic efficacy of radioimmunot...

Radiotherapy is widely used in cancer treatment. In addition to inducing effects in the irradiated area, irradiation may induce effects on tissues close to and distant from the irradiated area. Japanese medaka, Oryzias latipes, is a small teleost fish and a model organism for evaluating the environmental effects of radiation. In this study, we applied low-energy carbon-ion (26.7 MeV/u) irradiat...

The accumulation of p53 protein following whole body irradiation of adult mice was studied using a new polyclonal antibody to mouse p53. While dramatic accumulation of the protein was apparent in splenocytes, thymocytes and osteocytes no p53 protein accumulation was detected in the hepatocytes of the irradiated mouse. Thus, the upstream initiating signals that control the induction of p53 are c...

The aim of present study was to investigate the potential antioxidant and lung protective activities of Sambucus ebulus (SE) against toxicity induced by gamma irradiation. Hydroalcoholic extract of SE (20, 50 and 100 mg/kg) was studied for its lung protective activity. Phenol and flavonoid contents of SE were determined. Male C57 mice were divided into ten groups with five mice per group. Only ...

Background: To evaluate the radioprotective potential of Punica granatum fruit rind extract (PGRE) in mouse testes. Materials and Methods: Adult male mice were divided into four groups. Group I was kept without any treatment. Group II was irradiated with 8Gy Co60 gamma irradiation and Group III was given PGRE one hour before irradiation. Group IV was fed with PGRE at the rate of 10 mg/kg body w...

The Gompertz model is the long-time well-known mathematical model of exponential expression among mortality models in the literature that are used to describe mortality and survival data of a population. The death rate of the “probacent” model developed by the author based on animal experiments, clinical applications and mathematical reasoning was applied to predict age-specific death rates in ...

*愼 殿玲子 ,**野 本亀久雄,**武 谷健二:九 州大学医学部放射線科学 教室,微 生物学 教室 福岡市東区馬 出3-1-1〒812 Radiosensitivity of T and B lymphocytes/In vivo X-irradiation/Immune Response to SRBC The effect of whole body irradiation on antibody response to sheep erythrocytes was investigated in C57BL/6 mice. 1) The degree of reduction in antibody production observed shortly after irradiation increased with the increase in X-ray dose. ...

Intestine is vulnerable to irradiation injury, which induces cell death and compromises regeneration of intestinal crypts. It is well accepted that cryptic stem cells, which are responsible for cryptic regeneration under physiological and pathological conditions, are controlled by multiple cell-intrinsic and environmental signals such as Notch signaling. Therefore, in the present study, we test...