/V-/j-Alanyldopamine (NBAD) has attracted a great deal of interest because of its significance in catecholamine metabolism in insects with which phenoloxidase is concerned.1' Kramer et al. synthesized NBADby coupling the acid component of /V-/?-alanine with the amine component of dopamine in aqueous solution.2' Their method, however, required several chromatographic steps to purify the syntheti...

Automatic classification of news articles is a relevant problem due to the large amount of news generated every day, so it is crucial that these news are classified to allow for users to access to information of interest quickly and effectively. Traditional classification systems represent documents as bag-of-words (BoW), which are oblivious to two problems of language: synonymy and polysemy. T...

A seven-step synthetic route has been developed to access the labile C-3 unsubstituted 5-phenylthiomorpholinone system for first time. The key step involved nucleophilic ring opening of Boc-phenylmorpholinone give corresponding methyl ester. sulfur introduction was accomplished through a Mitsunobu reaction yield thioacetate, which then hydrolysed provide thiol acid. Cyclization acid achieved us...

VIDEO ABSTRACT The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. Shh is expressed in layer V corticofugal projection neurons and the Shh recep...

One of the main challenges in Binary Offset Carrier (BOC) tracking is the presence of multiple peaks in the signal autocorrelation function. Thus, several tracking algorithms, including Bump-Jump, Double Estimator, Autocorrelation Side-Peak Cancellation Technique and pre-filtering have been developed to fully exploit the advantages brought by BOC signals and mitigate the problem of secondary pe...

Author(s) Lohan, Elena Simona; Burian, Adina; Renfors, Markku Title Low-complexity unambiguous acquisition methods for BOC-modulated CDMA signals Citation Lohan, Elena Simona; Burian, Adina; Renfors, Markku 2008. Low-complexity unambiguous acquisition methods for BOC-modulated CDMA signals. International journal of satellite communications vol. 26, num. 6, 503-522. Year 2008 DOI http://dx.doi.o...

An analogue of gramicidin A (gA) was synthesized with the formyl group replaced by a BOC group. The analogue (BOC-gA) exhibited single channel conduction, but the channel is 5-order-of-magnitude destabilized relative to the gA channel. Hydrated mixtures of gramicidin and dilauroyl phosphatidylcholine in the molar ratio of 1:10 were prepared into uniformly aligned multiple bilayers, and X-ray sc...

The four-step conversion of a series of N-Boc-protected l-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral β-ketosulfones, and the reductive elimination of related α-acetoxysulfones. The overall transformation takes place under mild condition...

Our previous studies showed that alteration of dipeptides Y-Fca-Ala-OMe (III) into Y-Ala-Fca-OMe (IV) (Y=Ac, Boc; Fca=1'-aminoferrocene-1-carboxylic acid) significantly influenced their conformational space. The novel bioconjugates Y-Fca-Pro-OMe (1, Y=Ac; 2, Y=Boc) and Y-Pro-Fca-OMe (3, Y=Boc; 4, Y=Ac) have been prepared in order to investigate the influence of proline, a well-known turn-induce...