A multi-functional mesoporous silica nanoparticle (MSN)-based boron neutron capture therapy (BNCT) agent, designated as T-Gal-B-Cy3@MSN, was synthesized with hydrophobic mesopores for incorporating a large amount of o-carborane (almost 60% (w/w) boron atoms per MSN), and the amines on the external surface were conjugated with trivalent galactosyl ligands and fluorescent dyes for cell targeting ...

This study aimed to evaluate the residual radioactivity in mice induced by neutron irradiation with an accelerator-based boron neutron capture therapy (BNCT) system using a solid Li target. The radionuclides and their activities were evaluated using a high-purity germanium (HP-Ge) detector. The saturated radioactivity of the irradiated mouse was estimated to assess the radiation protection need...

Boron Neutron Capture Therapy (BNCT) is a binary radiation treatment modality based on nuclear reactions between thermal neutrons and stable isotope B concentrated primarily in cancer cells. It allows for delivery of high linear energy transfer (LET) radiation ( particles and Li nuclei) to tumors at the cellular level whilst avoiding unnecessary dose deposition to healthy tissue. Until now, mos...

We report a case of a benign notochordal cell tumor (BNCT) of the sacrum with atypical imaging features, which was incidentally discovered in a 74-year-old man undergoing evaluation for progressively worsening hip and back pain. It is important for radiologists, pathologists and orthopedic surgeons to be aware of the diagnosis of BNCT and be familiar with its radiographic features to avoid unne...

Abstract Boron neutron capture therapy (BNCT) is a potential radiation modality for cancer, and tumor-targeted stable boron-10 ( 10 B) delivery agents are an important component of BNCT. Currently, two low-molecular-weight boron-containing compounds, sodium mercaptoundecahydro- closo -dodecaborate (BSH) boronophenylalanine (BPA), mainly used in Although both have suboptimal tumor selectivity, t...

In this study the synthesis and characterization of a new dual, imaging and therapeutic, agent is proposed with the aim of improving the efficacy of Boron Neutron Capture Therapy (BNCT) in cancer treatment. The agent (Gd-B-AC01) consists of a carborane unit (ten boron atoms) bearing a cholesterol unit on one side (to pursue the incorporation into the liposome bi-layer) and a Gd(iii)/1,4,7,10-te...

BACKGROUND Boron neutron capture therapy (BNCT) is a cell-selective radiation therapy that uses the alpha particles and lithium nuclei produced by the boron neutron capture reaction. BNCT is a relatively safe tool for treating multiple or diffuse malignant tumors with little injury to normal tissue. The success or failure of BNCT depends upon the 10B compound accumulation within tumor cells and...

To assess the effects of quinidine gluconate on left ventricular (LV) performance, sonomicrometer length gauges and micromanometer catheters were implanted in 17 conscious dogs. Studies were carried out before and after the development of volume overload LV hypertrophy induced by an aortocaval fistula. Quinidine gluconate was given intravenously in two successive doses of 6 mg/kg, yielding seru...