4NEMIAS COMPLICATING MALIGNANT NEOPLASMS may be seekt ondary to blood loss, increased blood destruction, invasion of the hemopoietic organs or represent a side effect of the myelo-depressive agents used in the treatment of the neoplasm. Often none of these etiologic factors can be demonstrated. The anemia is usually mild to moderate in severity (8 to 10 Gm. per cent ) and, less frequently, seve...

The aim of the present study was to determine changes in body iron storage in adult dogs following phlebotomy. We performed repeated phlebotomies by removing 1% body weight (approximately 10% of the total blood volume) weekly for a total of 12 times using adult beagle dogs without an iron-restricted diet. After treatment, stored iron was decreased, as demonstrated by gradual reductions in serum...

The aim of this study was to investigate the combined influence of diet, menstruation and genetic factors on iron status in Spanish menstruating women (n = 142). Dietary intake was assessed by a 72-h detailed dietary report and menstrual blood loss by a questionnaire, to determine a Menstrual Blood Loss Coefficient (MBLC). Five selected SNPs were genotyped: rs3811647, rs1799852 (Tf gene); rs137...

Background Chronic iron overload is prevalent and prognosis relates to the severity of cardiac siderosis. The black blood (BB) T2* technique is validated, with calibration against myocardial tissue iron at 1.5T. There are potential advantages of 3T over 1.5T in assessing T2*, but preliminary studies at 3T used white blood imaging, had small patient numbers, methodological differences, and poor ...

While pumping iron in barbell form might help you look more like Mr. Schwarzenegger [2], ?pumping iron? through your blood in mineral form is a critical component of your overall health. A constant supply of iron in your diet fuels the production of new red blood cells. These red blood cells contain hemoglobin, a complex protein-iron compound that carries oxygen from the lungs to all of the bod...

BACKGROUND Blood transfusion has been recognised as a risk factor for the development of retinopathy of prematurity (ROP) or chronic lung disease (CLD) in preterm infants, but the precise mechanism involved is not understood. AIM To investigate the level of non-transferrin bound "free" iron, which has the potential to promote the generation of reactive oxygen species, and its redox status in ...

Although, iron depletion is a common disorder among athletes, little data exist regarding the effect of gymnastic training on iron status. The objective of this study was to evaluate the effect of gymnastic exercise on body iron status and hematologic profile. The present investigation involved 35 male gymnasts aged from 6 to14 yrs. Serum ferritin level, total iron binding capacity (TIBC), iron...

BACKGROUND The clinical need to be able to administer high doses of intravenous iron conveniently in a single rapid infusion has been addressed by the recent introduction of ferric carboxymaltose and subsequently iron isomaltoside 1000. Neither requires a test dose. Ferric carboxymaltose can be administered at 15 mg/kg body weight to a maximum dose of 1000 mg, whereas iron isomaltoside 1000 can...

Shaheen et al. (1) recently reported that carriers of hemochromatosis (HFE) gene mutations have a statistically significantly increased risk of colon cancer. Taken together with other recent findings (2), these results suggest that heterozygosity for hemochromatosis confers increased risk of both colon cancer and cardiovascular disease in the approximately 15% of the U.S. population who are HFE...