OBJECTIVE The purpose of this study was to examine the effect of cigarette smoke exposure (CSE) on clot dynamics and fibrin architecture and to isolate the relative contribution of platelets and fibrinogen to clot dynamics. METHODS AND RESULTS From young healthy males smokers (n=34) and nonsmokers (n=34) a baseline blood was drawn, and smokers had another blood draw after smoking 2 regular ci...

BACKGROUND AND OBJECTIVE Protamine is routinely administered following cardiopulmonary bypass in order to neutralize the effects of heparin. An excess of protamine can contribute to coagulopathy, hence predisposing to bleeding with associated morbidity and mortality. Thromboelastography (TEG) is recognized as an invaluable bedside tool to detect coagulation parameters; however, the effects of p...

The aim of the study was to investigate the thrombolytic activity of Punica granatum and Azadirachta indica over canine, bovine, caprine and avian blood clot using streptokinase and water as positive and negative control respectively. Using an in vitro thrombolytic model, the clot lysis activity of A. indica was observed as 48.06±0.59%, 50.01±1%, 47.6±0.69% and 28.03±0.35% and of P. granatum as...

backgrounds and aims: methylglyoxal (mgo) is an –α, β dicarbonyl aldehyde inevitably produced from triose-phosphate intermediates of glycolysis, and amino acid. increased mgo in blood leads to alterations in coagulation, clot permeability and thus, atherosclerosis in children with diabetes; however, the precise mechanism is not clear. the present study aimed to compare different concentrations ...

BACKGROUND Sepsis induces early activation of coagulation and fibrinolysis followed by late fibrinolytic shutdown and progressive endothelial damage. The aim of the present study was to investigate and compare the functional hemostatic response in whole blood and plasma during experimental human endotoxemia by the platelet function analyzer, Multiplate and by standard and modified thrombelastog...

A serious pathological condition is encountered when some blood constituents deposited on the blood vessels get detached from the wall, join the blood stream again and form a clot. The pulsatile flow for peristaltic transport of a fluid with suspended particles may be considered as a mathematical model for the blood flow. We study this model in a annular region with a clot inside it, under low ...

The World Health Organization estimates that 17 million people die of cardiovascular disease, particularly heart attacks and strokes, every year. Most strokes are caused by a blood clot that occludes an artery in the cerebral circulation and the process concerning the removal of this obstruction involves catheterisation. The fundamental object of the presented study consists in determining and ...

A lumbrokinase gene encoding a blood-clot dissolving protein was cloned from earthworm (Eisenia fetida) by RT-PCR amplification. The gene designated as CST1 (GenBank No. AY840996) was sequence analyzed. The cDNA consists of 888 bp with an open reading frame of 729 bp, which encodes 242 amino acid residues. Multiple sequence alignments revealed that CST1 shares similarities and conserved amino a...