Recent experiments have shown that the perovskite to post-perovskite phase transformation in CaIrO3 occurs more readily at room temperature when a shear stress is applied as compared to isotropic pressure. To understand this mechanistically, we have calculated the minimum-energy pathway of the phase transition with density functional theory under different pressure conditions with the generaliz...

Blood–Brain Barrier In article number 2100812 by Smriti Singh, Agnieszka Morgenroth, and co-workers, Matrix metalloprotease (MMP) sensitive nanogels are synthesized for effective delivery of a radiopharmaceutical ([125I]ITdU) across the blood-brain barrier (BBB). The show efficient transcytosis in vitro model BBB co-cultured with glioblastoma cells. Once transcytosed, degrade an up-regulated MM...

Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...