Blister beetle is an important insect model for both medicinal and pure research. Previous research has mainly focused on its biology and biochemistry, but very little data is yet available in the molecular biology. This study uses differential proteomics technology to analyze the soluble proteins extracted from each of the 5 instars larvae of Epicauta chinensis. 42 of the differentially-expres...

Cantharis Q has a long history in both folk and traditional medicine being used as an aphrodisiac. It is a crude alcoholic extract of blister beetle Lytta vesicatoria commonly known as Spanish fly having cantharidin, a venomous substance present in it. The aim of the present study was to evaluate the clinical application of Cantharis Q by assessing its effect on the vital organ, liver, for a ...

INTRODUCTION Matrix metalloproteinases (MMPs) have various roles in inflammatory states. They seem to be able to modulate endothelial barriers and regulate the activity of chemokines and cytokines. The timely development of the levels during severe sepsis and thereafter have not been investigated. In addition it was of interest to study alterations of MMP-levels in intact skin, as the skin is t...

the carabid beetle pterostichus (phonias) strenuus (panzer) is newly recorded from iran. it was collected by hand from ghaleroudkhan forests in the caspian province of guilan. this carabid beetle is widely distributed throughout the palaearctic region including europe, uzbekistan, kazakhstan and russian far east.

ptinidae or spider beetles, is a worldwide family of beetles especially distributed in the subtropical and temperate zones including iran. niptus holoeucus (golden spider beetle) from kangohar cave in fars province (iran) is described as new record for iran. we regarded this beetle as a troglophile and guanophile species.

Cantharidin, a potent vesicant and antifeedant agent, is produced by two families of beetles, Meloidae and Oedemeridae (Coleoptera). In this study, the cantharidin content of oedemerid beetles of central Iran was investigated using the GC-MS method. Cantharidin in both sexes of Oedemera podagrariae ventralis Meïneïtrieãs (Oedemeridae) was found in an average of 3.89 µg/beetle in males and 21.68...

The pharmacokinetics of the broad-spectrum penicillin Bay k 4999 were studied in six healthy male volunteers. A 2-g dose was given by the intravenous route. The tissue penetration of the antibiotic was studied by both dermabrasion and blister techniques. A total of 26.4% of the drug was recovered in the urine in 24 h, 79% of this being excreted in the first 2 h. The elimination half-life in ser...

Copyright © 2012 Frederick Furness Publishing 16 In this paper, Thomas Dries, PhD, Market Development Manager Europe, Healthcare & Packaging, Honeywell Specialty Materials, considers the challenges facing the pharmaceutical industry in implementing a blister packaging strategy that: protects advanced solid oral drug delivery systems from physical or chemical degradation; creates market advantag...

Although the blister model for the Orion Nebula is widely accepted, an alternative model, where the optical appearance of the nebula is primarily determined by self-extinction, continues to be considered by some and has never specifically been disproven. I summarize the characteristics of the two models and show that the evidence falls overwhelmingly against the self-extinction model and in fav...

A 500-mg dose of the quinoline ciprofloxacin was administered orally to each of six healthy male volunteers, after which the concentrations of this agent in serum and blister fluid were measured. Absorption appeared to be rapid, with a mean peak level of 2.4 micrograms/ml attained 1.25 h after administration. The serum elimination half-life was 3.9 h. The agent penetrated blister fluid well, th...