Infection prevention and control (IPC) measures put in place during the first phases of COVID-19 pandemic were effective reducing endoscopy-related transmission while allowing recovery activity. In late 2020 a novel, more infectious, SARS-CoV-2 variant (VOC 202012/01) was associated with second ’surge' or acceleration phase UK. We sought to measure whether pre-existing IPC guidance would be su...

Abstract Oncolytic viruses are considered part of immunotherapy and have shown promise in preclinical experiments clinical trials a small fraction patients. To improve the response rate, it is necessary to reshape tumor microenvironment that shields from immune system patient. We engineered Delta-24-RGDOX (DNX-2440), an oncolytic adenovirus express T-cell activator OX40L, which triggered, murin...

Hydroxychloroquine (HCQ) dosage required to reach circulating levels that inhibit SARS-Cov-2 are extrapolated from pharmacokinetic data in non-COVID-19 patients. We performed a population-pharmacokinetic analysis 104 consecutive COVID-19 hospitalized patients (31 intensive care units, 73 medical wards, n = 149 samples). Plasma HCQ concentration were measured using high performance liquid chroma...

Background—Sudden cardiac death and life-threatening ventricular arrhythmia remain a concern in adult patients with repaired tetralogy of Fallot. Longitudinal left ventricular (LV) function is sensitive in detecting early myocardial damage and may have prognostic implications in this setting. Methods and Results—We included 413 tetralogy of Fallot patients (age, 36 13 years; QRS duration, 148 2...

AIMS To perform a toxicological analysis of deaths involving methadone and to determine the fatal concentration of methadone in such deaths. METHODS Deaths in which methadone was mentioned in the cause of death were identified. Deaths were divided into those associated with methadone only and deaths in which the cause of death was a combination of methadone and other drugs. Toxicological find...

Left ventricular hypertrophy (LVH), assessed by ECG, is associated with an increased risk for cardiovascular events among hypertensive subjects. We evaluated the risks of LVH in a Japanese general population including normotensive and prehypertensive subjects. We measured ECG and blood pressure in 10 755 subjects at baseline. The Cornell product (CP) and Sokolow-Lyon (SL) voltage were calculate...

Early-born γ-aminobutyric acid (GABA) neurons (EBGNs) are major components of the hippocampal circuit because at early postnatal stages they form a subpopulation of "hub cells" transiently supporting CA3 network synchronization (Picardo et al. [2011] Neuron 71:695-709). It is therefore essential to determine when these cells acquire the remarkable morphofunctional attributes supporting their ne...